Autotaxin inhibitor compound 1
Modify Date: 2025-08-23 11:49:42
Autotaxin inhibitor compound 1 structure
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Common Name | Autotaxin inhibitor compound 1 | ||
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| CAS Number | 1619971-30-0 | Molecular Weight | 405.45 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C21H23N7O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Autotaxin inhibitor compound 1Autotaxin-IN-1 is a potent autotaxin inhibitor, which has favorable potency (IC50=2.2 nM), PK properties, and a robust PK/PD relationship. Autotaxin-IN-1 is used in treatment of osteoarthritis pain[1]. |
| Name | Autotaxin-IN-1 |
|---|
| Description | Autotaxin-IN-1 is a potent autotaxin inhibitor, which has favorable potency (IC50=2.2 nM), PK properties, and a robust PK/PD relationship. Autotaxin-IN-1 is used in treatment of osteoarthritis pain[1]. |
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| Related Catalog | |
| Target |
Autotaxin:2 nM (IC50) |
| In Vivo | Autotaxin-IN-1 (i.v.; 1.0mg/kg) has T1/2 of 1.14 hours[1]. Autotaxin-IN-1 (p.o.; 10 mg/kg) has Cmax of 660 nM and AUC of 3440 nM•h[1]. Animal Model: Normal rat[1] Dosage: 1.0 mg/kg, 10 mg/kg (Pharmacokinetic Study) Administration: I.v. (1.0 mg/kg); p.o. (10 mg/kg) Result: Has T1/2 of 1.14 hours (i.v.; 1.0mg/kg). Has Cmax of 660 nM and AUC of 3440 nM▪h (p.o.; 10 mg/kg). |
| References |
| Molecular Formula | C21H23N7O2 |
|---|---|
| Molecular Weight | 405.45 |
| InChIKey | ILOFWCAZDNILKY-UHFFFAOYSA-N |
| SMILES | O=C(COCCc1cn[nH]n1)N1Cc2cnc(NC3Cc4ccccc4C3)nc2C1 |
| Storage condition | -20°C |