SDZ 224-015

Modify Date: 2024-01-10 10:39:35

SDZ 224-015 structure	Common Name	SDZ 224-015
	CAS Number	161511-45-1	Molecular Weight	652.52
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₃₀H₃₅Cl₂N₃O₉	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of SDZ 224-015

SDZ 224-015 is an orally active inhibitor of the interleukin-1 beta (IL-1β) converting enzyme and caspase-1. SDZ 224-015 possesses anti-COVID-19 activity, targeting Mpro (IC50 of 30 nM)[1][2].

Name	SDZ 224-015

Description	SDZ 224-015 is an orally active inhibitor of the interleukin-1 beta (IL-1β) converting enzyme and caspase-1. SDZ 224-015 possesses anti-COVID-19 activity, targeting Mpro (IC50 of 30 nM)[1][2].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Immunology/Inflammation >> Interleukin Related Signaling Pathways >> Anti-infection >> SARS-CoV Signaling Pathways >> Apoptosis >> Caspase Research Areas >> Inflammation/Immunology
In Vivo	SDZ 224-015 (0.3-300 μg/kg) potently reduces carrageenin-induced paw oedema[2]. SDZ 224-015 (0.2-5 mg/kg, p.o.) displays analgesic activity in the Randall-Selitto yeast-inflamed paw pressure test, significant at a dose of 1 mg/kg[2].
References	[1]. Martin A Redhead, et al. Bispecific repurposed medicines targeting the viral and immunological arms of COVID-19. Sci Rep. 2021 Jun 24;11(1):13208. [2]. P R Elford, et al. Reduction of inflammation and pyrexia in the rat by oral administration of SDZ 224-015, an inhibitor of the interleukin-1 beta converting enzyme. Br J Pharmacol. 1995 Jun;115(4):601-6.

Molecular Formula	C₃₀H₃₅Cl₂N₃O₉
Molecular Weight	652.52

DC Chemicals Limited
China
Product Name: SDZ 224-015
Price: ￥Inquiry/1g
Purity: 98.9%
Stocking Period: 1 Day
Contact: Tony Cao

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