TH 588
Modify Date: 2025-08-26 20:05:49
TH 588 structure
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Common Name | TH 588 | ||
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| CAS Number | 1609960-31-7 | Molecular Weight | 295.167 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 545.7±60.0 °C at 760 mmHg | |
| Molecular Formula | C13H12Cl2N4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 283.9±32.9 °C | |
Use of TH 588TH588 is first-in-class nudix hydrolase family inhibitor that potently and selectively engage and inhibit the MTH1(IC50= 5 nM) in cells.IC50 value: 5 nM [1]Target: MTH1 inhibitorTH588 is highly selective towards MTH1, with no relevant inhibition of other members of the nudix protein family or a panel of 87 enzymes, GPCRs, kinases, ion channels and transporter. TH588 has been shown to selectively kill a variety of cancer cell lines and with in vivo activity shown for TH588 in SW480 colorectal and MCF7 breast tumour xenografts. |
| Name | N4-Cyclopropyl-6-(2,3-dichlorophenyl)-2,4-pyrimidinediamine |
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| Synonym | More Synonyms |
| Description | TH588 is first-in-class nudix hydrolase family inhibitor that potently and selectively engage and inhibit the MTH1(IC50= 5 nM) in cells.IC50 value: 5 nM [1]Target: MTH1 inhibitorTH588 is highly selective towards MTH1, with no relevant inhibition of other members of the nudix protein family or a panel of 87 enzymes, GPCRs, kinases, ion channels and transporter. TH588 has been shown to selectively kill a variety of cancer cell lines and with in vivo activity shown for TH588 in SW480 colorectal and MCF7 breast tumour xenografts. |
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| Related Catalog | |
| References |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 545.7±60.0 °C at 760 mmHg |
| Molecular Formula | C13H12Cl2N4 |
| Molecular Weight | 295.167 |
| Flash Point | 283.9±32.9 °C |
| Exact Mass | 294.043915 |
| LogP | 3.85 |
| Appearance of Characters | white solid |
| Vapour Pressure | 0.0±1.5 mmHg at 25°C |
| Index of Refraction | 1.725 |
| InChIKey | PNMYJIOQIAEYQL-UHFFFAOYSA-N |
| SMILES | Nc1nc(NC2CC2)cc(-c2cccc(Cl)c2Cl)n1 |
| Storage condition | -20℃ |
| 2,4-Pyrimidinediamine, N-cyclopropyl-6-(2,3-dichlorophenyl)- |
| N-Cyclopropyl-6-(2,3-dichlorophenyl)-2,4-pyrimidinediamine |
| TH588 |