TH287
Modify Date: 2024-01-07 21:06:42
TH287 structure
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Common Name | TH287 | ||
|---|---|---|---|---|
| CAS Number | 1609960-30-6 | Molecular Weight | 269.130 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 512.2±60.0 °C at 760 mmHg | |
| Molecular Formula | C11H10Cl2N4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 263.5±32.9 °C | |
Use of TH287TH287 is a potent inhibitor of MTH1 (NUDT1) with an IC50 value of 0.8 nM, less potent for MTH2, NUDT5, NUDT12, NUDT14, and NUDT16.IC50 value: 0.8 nM [1]Target: MTH1 inhibitorTH287 is considered a new target for cancer therapy. TH287 is highly selective towards MTH1, with no relevant inhibition of other members of the nudix protein family. TH287 has been shown to selectively kill a variety of cancer cell lines, but is rapidly metablized, so not as useful for in vivo studies. |
| Name | th287 |
|---|---|
| Synonym | More Synonyms |
| Description | TH287 is a potent inhibitor of MTH1 (NUDT1) with an IC50 value of 0.8 nM, less potent for MTH2, NUDT5, NUDT12, NUDT14, and NUDT16.IC50 value: 0.8 nM [1]Target: MTH1 inhibitorTH287 is considered a new target for cancer therapy. TH287 is highly selective towards MTH1, with no relevant inhibition of other members of the nudix protein family. TH287 has been shown to selectively kill a variety of cancer cell lines, but is rapidly metablized, so not as useful for in vivo studies. |
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| Related Catalog | |
| References |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 512.2±60.0 °C at 760 mmHg |
| Molecular Formula | C11H10Cl2N4 |
| Molecular Weight | 269.130 |
| Flash Point | 263.5±32.9 °C |
| Exact Mass | 268.028259 |
| PSA | 37.81000 |
| LogP | 3.48 |
| Appearance of Characters | white solid |
| Vapour Pressure | 0.0±1.3 mmHg at 25°C |
| Index of Refraction | 1.681 |
| Storage condition | 2-8℃ |
| 6-(2,3-dichlorophenyl)-N4-methylpyrimidine-2,4-diamine |
| 2,4-Pyrimidinediamine, 6-(2,3-dichlorophenyl)-N-methyl- |
| 6-(2,3-Dichlorophenyl)-N-methyl-2,4-pyrimidinediamine |