DY268

Modify Date: 2024-04-06 13:26:12

DY268 Structure
DY268 structure
Common Name DY268
CAS Number 1609564-75-1 Molecular Weight 560.664
Density 1.3±0.1 g/cm3 Boiling Point N/A
Molecular Formula C30H32N4O5S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of DY268


DY268 is a farnesoid X receptor (FXR) antagonist (IC50=7.5 nM in a time-resolved FRET assay). It inhibits FXR transactivation in a cell-based assay with an IC50 value of 468 nM[1].

 Names

Name DY 268
Synonym More Synonyms

 DY268 Biological Activity

Description DY268 is a farnesoid X receptor (FXR) antagonist (IC50=7.5 nM in a time-resolved FRET assay). It inhibits FXR transactivation in a cell-based assay with an IC50 value of 468 nM[1].
Related Catalog
References

[1]. Yu DD, Lin W, Forman BM, Chen T. Identification of trisubstituted-pyrazol carboxamide analogs as novel and potent antagonists of farnesoid X receptor. Bioorg Med Chem. 2014 Jun 1;22(11):2919-38.

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Molecular Formula C30H32N4O5S
Molecular Weight 560.664
Exact Mass 560.209351
LogP 3.65
Index of Refraction 1.638
Storage condition -20°C

 Synonyms

DY 268
1H-Pyrazole-4-carboxamide, 1-[(3-methoxyphenyl)methyl]-N-[4-methyl-3-(4-morpholinylsulfonyl)phenyl]-3-(4-methylphenyl)-
1-(3-Methoxybenzyl)-N-[4-methyl-3-(4-morpholinylsulfonyl)phenyl]-3-(4-methylphenyl)-1H-pyrazole-4-carboxamide