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DY268

Names

[ CAS No. ]:
1609564-75-1

[ Name ]:
DY268

[Synonym ]:
DY 268
1H-Pyrazole-4-carboxamide, 1-[(3-methoxyphenyl)methyl]-N-[4-methyl-3-(4-morpholinylsulfonyl)phenyl]-3-(4-methylphenyl)-
1-(3-Methoxybenzyl)-N-[4-methyl-3-(4-morpholinylsulfonyl)phenyl]-3-(4-methylphenyl)-1H-pyrazole-4-carboxamide

Biological Activity

[Description]:

DY268 is a farnesoid X receptor (FXR) antagonist (IC50=7.5 nM in a time-resolved FRET assay). It inhibits FXR transactivation in a cell-based assay with an IC50 value of 468 nM[1].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> FXR
Research Areas >> Metabolic Disease

[References]

[1]. Yu DD, Lin W, Forman BM, Chen T. Identification of trisubstituted-pyrazol carboxamide analogs as novel and potent antagonists of farnesoid X receptor. Bioorg Med Chem. 2014 Jun 1;22(11):2919-38.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Molecular Formula ]:
C30H32N4O5S

[ Molecular Weight ]:
560.664

[ Exact Mass ]:
560.209351

[ LogP ]:
3.65

[ Index of Refraction ]:
1.638

[ Storage condition ]:
-20°C

Related Compounds