Tilfrinib

Modify Date: 2024-01-10 11:40:41

Tilfrinib Structure
Tilfrinib structure
Common Name Tilfrinib
CAS Number 1600515-49-8 Molecular Weight 275.305
Density 1.4±0.1 g/cm3 Boiling Point 560.6±35.0 °C at 760 mmHg
Molecular Formula C17H13N3O Melting Point N/A
MSDS N/A Flash Point 292.8±25.9 °C

 Use of Tilfrinib


Tilfrinib (compound 4f) is a potent and selective inhibitor of breast tumor kinase (Brk) with an IC50 of 3.15 nM, which displays anti-proliferative activity and acts as a promising antitumor agent[1].

 Names

Name 3-(9H-Pyrido[2,3-b]indol-4-ylamino)phenol
Synonym More Synonyms

 Tilfrinib Biological Activity

Description Tilfrinib (compound 4f) is a potent and selective inhibitor of breast tumor kinase (Brk) with an IC50 of 3.15 nM, which displays anti-proliferative activity and acts as a promising antitumor agent[1].
Related Catalog
Target

IC50: 3.15 nM (Brk)[1]

References

[1]. Mahmoud KA, et al. Discovery of 4-anilino α-carbolines as novel Brk inhibitors. Bioorg Med Chem Lett. 2014 Apr 15;24(8):1948-51.

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 560.6±35.0 °C at 760 mmHg
Molecular Formula C17H13N3O
Molecular Weight 275.305
Flash Point 292.8±25.9 °C
Exact Mass 275.105865
LogP 4.69
Vapour Pressure 0.0±1.6 mmHg at 25°C
Index of Refraction 1.839

 Synonyms

3-(9H-Pyrido[2,3-b]indol-4-ylamino)phenol
Phenol, 3-(9H-pyrido[2,3-b]indol-4-ylamino)-
MFCD30011871
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