L-NIO dihydrochloride

Modify Date: 2025-08-26 09:44:31

L-NIO dihydrochloride structure	Common Name	L-NIO dihydrochloride
	CAS Number	159190-44-0	Molecular Weight	246.135
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₇H₁₇Cl₂N₃O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of L-NIO dihydrochloride

L-NIO dihydrochloride is a potent, non-selective and NADPH-dependent nitric oxide synthase (NOS) inhibitor, with Kis of 1.7, 3.9, 3.9 μM for neuronal (nNOS), endothelial (eNOS), and inducible (iNOS), respectively[1][2]. L-NIO dihydrochloride induces a consistentfocal ischemic infarctin rats[2].

Name	(E)-N5-(1-Aminoethylidene)-L-ornithine dihydrochloride
Synonym	More Synonyms

Description	L-NIO dihydrochloride is a potent, non-selective and NADPH-dependent nitric oxide synthase (NOS) inhibitor, with Kis of 1.7, 3.9, 3.9 μM for neuronal (nNOS), endothelial (eNOS), and inducible (iNOS), respectively[1][2]. L-NIO dihydrochloride induces a consistentfocal ischemic infarctin rats[2].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Immunology/Inflammation >> NO Synthase
Target	Ki: 1.7 μM (nNOS), 3.9 μM (eNOS), 3.9 μM (iNOS)[1]
References	[1]. Babu BR, et al. N5-(1-Imino-3-butenyl)-L-ornithine. A neuronal isoform selective mechanism-based inactivator of nitric oxide synthase. J Biol Chem. 1998 Apr 10;273(15):8882-9. [2]. Van Slooten AR, et al. L-NIO as a novel mechanism for inducing focal cerebral ischemia in the adult rat brain. J Neurosci Methods. 2015 Apr 30;245:44-57.

Molecular Formula	C₇H₁₇Cl₂N₃O₂
Molecular Weight	246.135
Exact Mass	245.069778
Appearance of Characters	NA
InChIKey	RYCMAAFECCXGHI-ILKKLZGPSA-N
SMILES	CC(N)=NCCCC(N)C(=O)O.Cl.Cl
Storage condition	2-8℃

(E)-N-(1-Aminoethylidene)-L-ornithine dihydrochloride

L-Ornithine, N-(1-aminoethylidene)-, (E)-, hydrochloride (1:2)

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L-NIO dihydrochloride

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