GR231118

Modify Date: 2025-08-24 12:46:51

GR231118 structure	Common Name	GR231118
	CAS Number	158859-98-4	Molecular Weight	2352.74000
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₁₀H₁₇₀N₃₄O₂₄	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of GR231118

GR231118, an analogue of the C-terminus of neuropeptide Y, is a potent , competitive and relative seletive antagonist at human neuropeptide Y Y receptor with a pKi of 10.4. GR231118 a potent agonist at the human neuropeptide Y Y4 receptor (pEC50=8.6; pKi=9.6) and a weak agonist at the human and rat neuropeptide YY2 and Y5 receptors. GR231118 also has high affinity for the mouse neuropeptide Y Y6 receptor (pKi= 8.8)[1].

Name	gr 231118

Description	GR231118, an analogue of the C-terminus of neuropeptide Y, is a potent , competitive and relative seletive antagonist at human neuropeptide Y Y receptor with a pKi of 10.4. GR231118 a potent agonist at the human neuropeptide Y Y4 receptor (pEC50=8.6; pKi=9.6) and a weak agonist at the human and rat neuropeptide YY2 and Y5 receptors. GR231118 also has high affinity for the mouse neuropeptide Y Y6 receptor (pKi= 8.8)[1].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> Neuropeptide Y Receptor
References	[1]. E M Parker, et al. GR231118 (1229U91) and other analogues of the C-terminus of neuropeptide Y are potent neuropeptide Y Y1 receptor antagonists and neuropeptide Y Y4 receptor agonists. Eur J Pharmacol [2]. Y Dumont, et al. [(125)I]-GR231118: a high affinity radioligand to investigate neuropeptide Y Y(1) and Y(4) receptors. Br J Pharmacol. 2000 Jan;129(1):37-46.

Description

Related Catalog

Research Areas >> Neurological Disease

Signaling Pathways >> GPCR/G Protein >> Neuropeptide Y Receptor

References

[1]. E M Parker, et al. GR231118 (1229U91) and other analogues of the C-terminus of neuropeptide Y are potent neuropeptide Y Y1 receptor antagonists and neuropeptide Y Y4 receptor agonists. Eur J Pharmacol

[2]. Y Dumont, et al. [(125)I]-GR231118: a high affinity radioligand to investigate neuropeptide Y Y(1) and Y(4) receptors. Br J Pharmacol. 2000 Jan;129(1):37-46.

Molecular Formula	C₁₁₀H₁₇₀N₃₄O₂₄
Molecular Weight	2352.74000
Exact Mass	2351.31000
PSA	972.96000
LogP	6.66460
InChIKey	RJRBRCCJETZJLT-GSICZYLSSA-N
SMILES	CCC(C)C(N)C(=O)NC1CCC(=O)NCC(C(=O)NC(Cc2ccc(O)cc2)C(=O)NC(CCCNC(=N)N)C(=O)NC(CC(C)C)C(=O)NC(CCCNC(=N)N)C(=O)NC(Cc2ccc(O)cc2)C(N)=O)NC(=O)C2CCCN2C(=O)C(NC(=O)C(N)C(C)CC)CCC(=O)NCC(C(=O)NC(Cc2ccc(O)cc2)C(=O)NC(CCCNC(=N)N)C(=O)NC(CC(C)C)C(=O)NC(CCCNC(=N)N)C(=O)NC(Cc2ccc(O)cc2)C(N)=O)NC(=O)C2CCCN2C1=O

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The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.