Hemiasterlin
Modify Date: 2024-02-01 18:44:56
Hemiasterlin structure
|
Common Name | Hemiasterlin | ||
|---|---|---|---|---|
| CAS Number | 157207-90-4 | Molecular Weight | 526.71100 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C30H46N4O4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of HemiasterlinHemiasterlin ((-)-Hemiasterlin) is an antimitotic marine natural product with potent anticancer effcts. Hemiasterlin can be used as a cytotoxic payload (ADC Cytotoxin) in antibody-drug conjugates (ADCs)[1]. |
| Name | (E,4S)-4-[[(2S)-3,3-dimethyl-2-[[(2S)-3-methyl-2-(methylamino)-3-(1-methylindol-3-yl)butanoyl]amino]butanoyl]-methylamino]-2,5-dimethylhex-2-enoic acid |
|---|---|
| Synonym | More Synonyms |
| Description | Hemiasterlin ((-)-Hemiasterlin) is an antimitotic marine natural product with potent anticancer effcts. Hemiasterlin can be used as a cytotoxic payload (ADC Cytotoxin) in antibody-drug conjugates (ADCs)[1]. |
|---|---|
| Related Catalog | |
| Target |
Pyrrolobenzodiazepines |
| In Vitro | Hemiasterlin is an antimitotic agent by disrupting microtubule dynamics causing mitotic arrest and cell death with low- to sub-nanomolar potencies against several cancer cell lines[1]. |
| References |
| Molecular Formula | C30H46N4O4 |
|---|---|
| Molecular Weight | 526.71100 |
| Exact Mass | 526.35200 |
| PSA | 107.16000 |
| LogP | 5.31990 |
| Milnamide B |
| UNII-6S0T7U2I3F |
| Hemiasterlin |