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Hemiasterlin

Names

[ CAS No. ]:
157207-90-4

[ Name ]:
Hemiasterlin

[Synonym ]:
Milnamide B
UNII-6S0T7U2I3F
Hemiasterlin

Biological Activity

[Description]:

Hemiasterlin ((-)-Hemiasterlin) is an antimitotic marine natural product with potent anticancer effcts. Hemiasterlin can be used as a cytotoxic payload (ADC Cytotoxin) in antibody-drug conjugates (ADCs)[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Antibody-drug Conjugate >> ADC Cytotoxin

[Target]

Pyrrolobenzodiazepines


[In Vitro]

Hemiasterlin is an antimitotic agent by disrupting microtubule dynamics causing mitotic arrest and cell death with low- to sub-nanomolar potencies against several cancer cell lines[1].

[References]

[1]. Jiraborrirak Charoenpattarapreeda, et al. Expeditious Total Synthesis of Hemiasterlin through a Convergent Multicomponent Strategy and Its Use in Targeted Cancer Therapeutics. Angew Chem Int Ed Engl. 2020 Dec 14;59(51):23045-23050.

Chemical & Physical Properties

[ Molecular Formula ]:
C30H46N4O4

[ Molecular Weight ]:
526.71100

[ Exact Mass ]:
526.35200

[ PSA ]:
107.16000

[ LogP ]:
5.31990

Related Compounds