Hemiasterlin

Names

[ Name ]:
Hemiasterlin

[Synonym ]:
Milnamide B
UNII-6S0T7U2I3F
Hemiasterlin

Biological Activity

[Description]:

Hemiasterlin ((-)-Hemiasterlin) is an antimitotic marine natural product with potent anticancer effcts. Hemiasterlin can be used as a cytotoxic payload (ADC Cytotoxin) in antibody-drug conjugates (ADCs)[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Antibody-drug Conjugate >> ADC Cytotoxin

[Target]

Pyrrolobenzodiazepines

[In Vitro]

Hemiasterlin is an antimitotic agent by disrupting microtubule dynamics causing mitotic arrest and cell death with low- to sub-nanomolar potencies against several cancer cell lines[1].

[References]

[1]. Jiraborrirak Charoenpattarapreeda, et al. Expeditious Total Synthesis of Hemiasterlin through a Convergent Multicomponent Strategy and Its Use in Targeted Cancer Therapeutics. Angew Chem Int Ed Engl. 2020 Dec 14;59(51):23045-23050.

Chemical & Physical Properties

[ Molecular Formula ]:
C₃₀H₄₆N₄O₄

[ Molecular Weight ]:
526.71100

[ Exact Mass ]:
526.35200

[ PSA ]:
107.16000

[ LogP ]:
5.31990

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.