Harzianic acid
Modify Date: 2024-01-14 13:43:00
Harzianic acid structure
|
Common Name | Harzianic acid | ||
|---|---|---|---|---|
| CAS Number | 157148-06-6 | Molecular Weight | 365.42100 | |
| Density | 1.233g/cm3 | Boiling Point | 539.8ºC at 760mmHg | |
| Molecular Formula | C19H27NO6 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 280.3ºC | |
Use of Harzianic acidHarzianic acid, a tetramic acid derivative, with activity of antimicrobial, antibiofilm formation and biofilm disaggregation. Harzianic acid interferes with biofilm formation by limiting bacterial iron availability. Harzianic acid is also a selective inhibitor of Acetohydroxyacid synthase (AHAS), the first enzyme in the branched-chain amino acid biosynthetic pathway. Harzianic acid can used for herbicide and fungicide[1][2]. |
| Name | 2-hydroxy-2-[[(4E)-4-[(2E,4E)-1-hydroxyocta-2,4-dienylidene]-1-methyl-3,5-dioxopyrrolidin-2-yl]methyl]-3-methylbutanoic acid |
|---|---|
| Synonym | More Synonyms |
| Description | Harzianic acid, a tetramic acid derivative, with activity of antimicrobial, antibiofilm formation and biofilm disaggregation. Harzianic acid interferes with biofilm formation by limiting bacterial iron availability. Harzianic acid is also a selective inhibitor of Acetohydroxyacid synthase (AHAS), the first enzyme in the branched-chain amino acid biosynthetic pathway. Harzianic acid can used for herbicide and fungicide[1][2]. |
|---|---|
| Related Catalog | |
| Target |
Acetohydroxyacid synthase (AHAS)[2] |
| In Vitro | Harzianic acid 对 MRSP 和 MSSP 表现出较强的抑菌活性，MIC 值分别为 32 μg/mL 和 16 μg/mL [1]。 Harzianic acid (8-128 μg/mL) 对 HaCaT 细胞毒性较低[1]。 Harzianic acid 作为一种竞争性抑制剂抑制真菌 ThAHAS, Ki 为 6.65 μM[2]。 Harzianic acid (0.1-100 μg/mL) 对病原真菌的生长有抑制作用[2]。 |
| References |
| Density | 1.233g/cm3 |
|---|---|
| Boiling Point | 539.8ºC at 760mmHg |
| Molecular Formula | C19H27NO6 |
| Molecular Weight | 365.42100 |
| Flash Point | 280.3ºC |
| Exact Mass | 365.18400 |
| PSA | 115.14000 |
| LogP | 1.92040 |
| Vapour Pressure | 6.63E-14mmHg at 25°C |
| Index of Refraction | 1.561 |
| Harzianic acid |