157148-06-6

157148-06-6 structure

Name: Harzianic acid
Chemical Name: 2-hydroxy-2-[[(4E)-4-[(2E,4E)-1-hydroxyocta-2,4-dienylidene]-1-methyl-3,5-dioxopyrrolidin-2-yl]methyl]-3-methylbutanoic acid
CAS Number: 157148-06-6
Molecular Formula: C₁₉H₂₇NO₆
Molecular Weight: 365.42100
Catalog: Signaling Pathways Anti-infection Fungal
Create Date: 2017-07-11 05:23:29
Modify Date: 2025-08-25 17:56:58
Harzianic acid, a tetramic acid derivative, with activity of antimicrobial, antibiofilm formation and biofilm disaggregation. Harzianic acid interferes with biofilm formation by limiting bacterial iron availability. Harzianic acid is also a selective inhibitor of Acetohydroxyacid synthase (AHAS), the first enzyme in the branched-chain amino acid biosynthetic pathway. Harzianic acid can used for herbicide and fungicide[1][2].

Name	2-hydroxy-2-[[(4E)-4-[(2E,4E)-1-hydroxyocta-2,4-dienylidene]-1-methyl-3,5-dioxopyrrolidin-2-yl]methyl]-3-methylbutanoic acid
Synonyms	Harzianic acid

Description	Harzianic acid, a tetramic acid derivative, with activity of antimicrobial, antibiofilm formation and biofilm disaggregation. Harzianic acid interferes with biofilm formation by limiting bacterial iron availability. Harzianic acid is also a selective inhibitor of Acetohydroxyacid synthase (AHAS), the first enzyme in the branched-chain amino acid biosynthetic pathway. Harzianic acid can used for herbicide and fungicide[1][2].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Fungal
Target	Acetohydroxyacid synthase (AHAS)[2]
In Vitro	Harzianic acid 对 MRSP 和 MSSP 表现出较强的抑菌活性，MIC 值分别为 32 μg/mL 和 16 μg/mL [1]。 Harzianic acid (8-128 μg/mL) 对 HaCaT 细胞毒性较低[1]。 Harzianic acid 作为一种竞争性抑制剂抑制真菌 ThAHAS, Ki 为 6.65 μM[2]。 Harzianic acid (0.1-100 μg/mL) 对病原真菌的生长有抑制作用[2]。
References	[1]. De Filippis A, et al. Antimicrobial activity of harzianic acid against Staphylococcus pseudintermedius. Nat Prod Res. 2021 Dec;35(23):5440-5445. [2]. Xie L, et al. Harzianic Acid from Trichoderma afroharzianum Is a Natural Product Inhibitor of Acetohydroxyacid Synthase. J Am Chem Soc. 2021 Jun 16:10.1021/jacs.1c03988.