3-Oxo-5β-cholanoic acid

Modify Date: 2025-09-01 14:00:27

3-Oxo-5β-cholanoic acid structure	Common Name	3-Oxo-5β-cholanoic acid
	CAS Number	1553-56-6	Molecular Weight	374.55700
	Density	1.069 g/cm3	Boiling Point	509.3ºC
	Molecular Formula	C₂₄H₃₈O₃	Melting Point	N/A
	MSDS	N/A	Flash Point	275.9ºC

Use of 3-Oxo-5β-cholanoic acid

3-Oxo-5β-cholanoic acid (Dehydrolithocholic acid), a bile acid metabolite, inhibits the diferentiation of TH17 cells by directly binding to the key transcription factor RORγt (Kd=1.13 μM)[1].

Name	3-oxo-5β-cholanic acid
Synonym	More Synonyms

Description	3-Oxo-5β-cholanoic acid (Dehydrolithocholic acid), a bile acid metabolite, inhibits the diferentiation of TH17 cells by directly binding to the key transcription factor RORγt (Kd=1.13 μM)[1].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> ROR Research Areas >> Inflammation/Immunology
In Vitro	Treatment with 3-Oxo-5β-cholanoic acid significantly reduced the activity of the RORγt reporter. These data suggest that 3-Oxo-5β-cholanoic acid probably inhibits TH17 cell differentiation by physically interacting with RORγt, and inhibiting its transcriptional activity[1].
In Vivo	3-Oxo-5β-cholanoic acid (Dehydrolithocholic acid) (0.3% (w/w); p.o.; for 1 week) significantly reduces the percentage of ileal TH17 cells[1]. Animal Model: B6 Jax mice (with a faecal slurry containing SFB)[1] Dosage: 0.3% (w/w) Administration: Gavaged; for 1 week Result: Significantly reduced the percentage of ileal TH17 cells.
References	[1]. Hang S, et al. Bile acid metabolites control TH17 and Treg cell differentiation. Nature. 2019 Dec;576(7785):143-148.

Density	1.069 g/cm3
Boiling Point	509.3ºC
Molecular Formula	C₂₄H₃₈O₃
Molecular Weight	374.55700
Flash Point	275.9ºC
Exact Mass	374.28200
PSA	54.37000
LogP	5.71530
Vapour Pressure	0mmHg at 25°C
Index of Refraction	1.52

3-Oxo-5β-cholanoic acid MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: FZ2281400

CHEMICAL NAME :: 5-beta-Cholan-24-oic acid, 3-oxo-

CAS REGISTRY NUMBER :: 1553-56-6

LAST UPDATED :: 199410

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C24-H38-O3

MOLECULAR WEIGHT :: 374.62

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Salmonella typhimurium

DOSE/DURATION :: 250 ug/disc

REFERENCE :: CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- Volume(issue)/page/year: 4,1179,1983

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Detail

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