(S)-3,4-Dihydro-4-hydroxy-2-(3-methoxypropyl)-2H-thieno[3,2-e]-1,2-thiazine-6-sulfonamide 1,1-dioxide

Modify Date: 2024-01-02 20:00:59

(S)-3,4-Dihydro-4-hydroxy-2-(3-methoxypropyl)-2H-thieno[3,2-e]-1,2-thiazine-6-sulfonamide 1,1-dioxide Structure
(S)-3,4-Dihydro-4-hydroxy-2-(3-methoxypropyl)-2H-thieno[3,2-e]-1,2-thiazine-6-sulfonamide 1,1-dioxide structure
Common Name (S)-3,4-Dihydro-4-hydroxy-2-(3-methoxypropyl)-2H-thieno[3,2-e]-1,2-thiazine-6-sulfonamide 1,1-dioxide
CAS Number 154127-42-1 Molecular Weight 356.43900
Density 1.575 g/cm3 Boiling Point 612.4ºC at 760 mmHg
Molecular Formula C10H16N2O6S3 Melting Point N/A
MSDS N/A Flash Point 324.2ºC

 Names

Name (S)-4-Hydroxy-2-(3-methoxypropyl)-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazine-6-sulfonamide 1,1-dioxide
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.575 g/cm3
Boiling Point 612.4ºC at 760 mmHg
Molecular Formula C10H16N2O6S3
Molecular Weight 356.43900
Flash Point 324.2ºC
Exact Mass 356.01700
PSA 172.00000
LogP 2.26950
Vapour Pressure 7.49E-16mmHg at 25°C
Index of Refraction 1.615

 Safety Information

Hazard Codes Xi
HS Code 2935009090

 Synthetic Route

~64%

(S)-3,4-Dihydro-4-hydroxy-2-(3-methoxypropyl)-2H-thieno[3,2-e]-1,2-thiazine-6-sulfonamide 1,1-dioxide Structure

(S)-3,4-Dihydro...

CAS#:154127-42-1

Literature: AZAD PHARMACEUTICAL INGREDIENTS AG; RAMAKRISHNAN, Arul; SONI, Anil Kumar; ADHIKARI, Sujit Das; RAO, Kommula Srinivasa; PAUL, Soumendu; SRINIVASULU, Ganta Patent: WO2010/103115 A1, 2010 ; Location in patent: Page/Page column 15-16 ;

~89%

(S)-3,4-Dihydro-4-hydroxy-2-(3-methoxypropyl)-2H-thieno[3,2-e]-1,2-thiazine-6-sulfonamide 1,1-dioxide Structure

(S)-3,4-Dihydro...

CAS#:154127-42-1

Literature: Alcon Laboratories, Inc. Patent: US5378703 A1, 1995 ;

~%

(S)-3,4-Dihydro-4-hydroxy-2-(3-methoxypropyl)-2H-thieno[3,2-e]-1,2-thiazine-6-sulfonamide 1,1-dioxide Structure

(S)-3,4-Dihydro...

CAS#:154127-42-1

Literature: Organic Process Research and Development, , vol. 3, # 2 p. 114 - 120

~59%

(S)-3,4-Dihydro-4-hydroxy-2-(3-methoxypropyl)-2H-thieno[3,2-e]-1,2-thiazine-6-sulfonamide 1,1-dioxide Structure

(S)-3,4-Dihydro...

CAS#:154127-42-1

Literature: Sathe, Dhananjay Govind; Tarur, Radhakrishnan Venkatasubramanian; Bhise, Nandu Baban; Shinde, Ajit Bhaskar; Pardeshi, Santosh Patent: US2010/9977 A1, 2010 ; Location in patent: Page/Page column 11 ;

~61%

(S)-3,4-Dihydro-4-hydroxy-2-(3-methoxypropyl)-2H-thieno[3,2-e]-1,2-thiazine-6-sulfonamide 1,1-dioxide Structure

(S)-3,4-Dihydro...

CAS#:154127-42-1

Literature: Conrow, Raymond E.; Dean, W. Dennis; Zinke, Paul W.; Deason, Michael E.; Sproull, Steven J.; Dantanarayana, Anura P.; DuPriest, Mark T. Organic Process Research and Development, 1999 , vol. 3, # 2 p. 114 - 120

~%

(S)-3,4-Dihydro-4-hydroxy-2-(3-methoxypropyl)-2H-thieno[3,2-e]-1,2-thiazine-6-sulfonamide 1,1-dioxide Structure

(S)-3,4-Dihydro...

CAS#:154127-42-1

Literature: Organic Process Research and Development, , vol. 3, # 2 p. 114 - 120

 Customs

HS Code 2935009090
Summary 2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%

 Synonyms

(4S)-4-hydroxy-2-(3-methoxypropyl)-1,1-dioxo-3,4-dihydrothieno[3,2-e]thiazine-6-sulfonamide
(S)-3,4-Dihydro-4-hydroxy-2-(3-methoxypropyl)-2H-thieno[3,2-e]-1,2-thiazine-6-sulfonamide 1,1-dioxide
Brinzolamide Impurity 5
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