Piperazine Erastin
Modify Date: 2024-01-05 17:10:17
Piperazine Erastin structure
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Common Name | Piperazine Erastin | ||
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| CAS Number | 1538593-71-3 | Molecular Weight | 645.19 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C35H41ClN6O4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Piperazine ErastinPiperazine erastin is an analog of erastin which induces an iron-dependent form of non-apoptotic cell death, termed ferroptosis. |
| Name | Piperazine Erastin |
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| Description | Piperazine erastin is an analog of erastin which induces an iron-dependent form of non-apoptotic cell death, termed ferroptosis. |
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| Related Catalog | |
| In Vitro | Erastin is a ferroptosis activator. It triggers a unique iron-dependent form of non-apoptotic cell death that is termed as ferroptosis. Piperazine erastin is a more effective analog of erastin which is more water-soluble (0.086 mM for erastin versus 1.4 mM for piperazine erastin) and more metabolically stable. Piperazine erastin is affected similarly by cell death modulators as erastin and displays a distinct pattern from other non-FIN lethal compounds[1]. |
| In Vivo | In the xenograft mouse model, a significant delay in tumor growth is observed in the piperazine erastin-treated group compared to the vehicle-treated group. Ptgs2 is upregulated in mouse liver with 10 or 60 mg/kg piperazine erastin administration[1]. |
| Animal Admin | Mice: Athymic nude mice are injected with four million HT-1080 cells s.c. The next day, 400 μL of vehicle (0.625% DMSO/99.375% HBSS [pH 2]) or 40 mg/kg piperazine erastin is delivered to the s.c. site where cancer cells are injected. Two days later, the s.c. injection is repeated. Three days later, 300 μL of vehicle or 30 mg/kg piperazine erastin is administered to the mice through tail vein. Tail vein injection is repeated three more times, once every other day before the final tumor size is measured in both groups[1]. |
| References |
| Molecular Formula | C35H41ClN6O4 |
|---|---|
| Molecular Weight | 645.19 |
| Storage condition | 2-8℃ |