5-Fluorouridine 5'-O-β-D-galactopyranoside

Modify Date: 2024-01-13 22:01:48

5-Fluorouridine 5'-O-β-D-galactopyranoside Structure
5-Fluorouridine 5'-O-β-D-galactopyranoside structure
Common Name 5-Fluorouridine 5'-O-β-D-galactopyranoside
CAS Number 149965-92-4 Molecular Weight 424.33200
Density 1.815g/cm3 Boiling Point N/A
Molecular Formula C15H21FN2O11 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of 5-Fluorouridine 5'-O-β-D-galactopyranoside


5-Fluorouridine 5'-O-β-D-galactopyranoside (5'-O-β-D-galactosyl-5-fluorouridine) is a 5-Fluorouridine prodrug. 5-Fluorouridine 5'-O-β-D-galactopyranoside can be converted by the enzyme β-D-galactosidase to the potent antineoplastic agent 5-Fluorouridine[1].

 Names

Name 5-Fluorouridine-5'-O-b-D-galactopyranoside
Synonym More Synonyms

  Biological Activity

Description 5-Fluorouridine 5'-O-β-D-galactopyranoside (5'-O-β-D-galactosyl-5-fluorouridine) is a 5-Fluorouridine prodrug. 5-Fluorouridine 5'-O-β-D-galactopyranoside can be converted by the enzyme β-D-galactosidase to the potent antineoplastic agent 5-Fluorouridine[1].
Related Catalog
In Vitro The ratio of the IC50 of 5-Fluorouridine 5'-O-β-D-galactopyranoside (5'-O-β-D-galactosyl-5-fluorouridine) to that of 5-Fluorouridine determined on a variety of tumor cell lines in vitro ranged from 500:1-1000:1[1].
In Vivo 5-Fluorouridine 5'-O-β-D-galactopyranoside (5'-O-β-D-galactosyl-5-fluorouridine) is more than 100x less toxic than 5-Fluorouridine to bone marrow cells in Balb/c mice[1].
References

[1]. R Abraham, et al. Conjugates of COL-1 monoclonal antibody and beta-D-galactosidase can specifically kill tumor cells by generation of 5-fluorouridine from the prodrug beta-D-galactosyl-5-fluorouridine. Cell Biophys. 1994;24-25:127-33.

 Chemical & Physical Properties

Density 1.815g/cm3
Molecular Formula C15H21FN2O11
Molecular Weight 424.33200
Exact Mass 424.11300
PSA 203.93000
Index of Refraction 1.668

 Synonyms

MFCD06799389