149965-92-4

149965-92-4 structure

Name: 5-Fluorouridine 5'-O-β-D-galactopyranoside
Chemical Name: 5-Fluorouridine-5'-O-b-D-galactopyranoside
CAS Number: 149965-92-4
Molecular Formula: C₁₅H₂₁FN₂O₁₁
Molecular Weight: 424.33200
Catalog: Research Areas Cancer
Create Date: 2018-11-27 15:10:55
Modify Date: 2024-01-13 22:01:48
5-Fluorouridine 5'-O-β-D-galactopyranoside (5'-O-β-D-galactosyl-5-fluorouridine) is a 5-Fluorouridine prodrug. 5-Fluorouridine 5'-O-β-D-galactopyranoside can be converted by the enzyme β-D-galactosidase to the potent antineoplastic agent 5-Fluorouridine[1].

Name	5-Fluorouridine-5'-O-b-D-galactopyranoside
Synonyms	MFCD06799389

Description	5-Fluorouridine 5'-O-β-D-galactopyranoside (5'-O-β-D-galactosyl-5-fluorouridine) is a 5-Fluorouridine prodrug. 5-Fluorouridine 5'-O-β-D-galactopyranoside can be converted by the enzyme β-D-galactosidase to the potent antineoplastic agent 5-Fluorouridine[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
In Vitro	The ratio of the IC50 of 5-Fluorouridine 5'-O-β-D-galactopyranoside (5'-O-β-D-galactosyl-5-fluorouridine) to that of 5-Fluorouridine determined on a variety of tumor cell lines in vitro ranged from 500:1-1000:1[1].
In Vivo	5-Fluorouridine 5'-O-β-D-galactopyranoside (5'-O-β-D-galactosyl-5-fluorouridine) is more than 100x less toxic than 5-Fluorouridine to bone marrow cells in Balb/c mice[1].
References	[1]. R Abraham, et al. Conjugates of COL-1 monoclonal antibody and beta-D-galactosidase can specifically kill tumor cells by generation of 5-fluorouridine from the prodrug beta-D-galactosyl-5-fluorouridine. Cell Biophys. 1994;24-25:127-33.