Chrysosplenol D
Modify Date: 2025-08-20 14:25:24
Chrysosplenol D structure
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Common Name | Chrysosplenol D | ||
|---|---|---|---|---|
| CAS Number | 14965-20-9 | Molecular Weight | 360.315 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 645.0±55.0 °C at 760 mmHg | |
| Molecular Formula | C18H16O8 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 237.3±25.0 °C | |
Use of Chrysosplenol DChrysosplenol D is a methoxy flavonoid that induces ERK1/2-mediated apoptosis in triple negative human breast cancer cells. Chrysosplenol D also exhibits anti-inflammatory and moderate antitrypanosomal activities[1][2][3][4]. |
| Name | 2-(3,4-dihydroxyphenyl)-5-hydroxy-3,6,7-trimethoxychromen-4-one |
|---|---|
| Synonym | More Synonyms |
| Description | Chrysosplenol D is a methoxy flavonoid that induces ERK1/2-mediated apoptosis in triple negative human breast cancer cells. Chrysosplenol D also exhibits anti-inflammatory and moderate antitrypanosomal activities[1][2][3][4]. |
|---|---|
| Related Catalog | |
| In Vitro | Chrysosplenol D inhibits the cell viability of CaCo2 cells, with IC50 of 63.48 μM[1]. Chrysosplenol D (1-100 μM; 48 h) selectively inhibits the viability of the TNBC cell lines, MDA-MB-231, CAL-51, CAL-148, as well as MCF7, A549, MIA PaCa-2, and PC-3[2]. Chrysosplenol D (1-10 μM; 48 h) induces cell cycle aberrations with accumulation of cells in the S-phase and partially in the G2/M-phase of the cell cycle[2]. Chrysosplenol D (1-10 μM; 48 h) induce apoptosis in breast cancer cells[2]. Chrysosplenol D shows moderate antitrypanosomal activity, with IC50 of 47.27 μM for T.b. brucei[3]. |
| In Vivo | Chrysosplenol D (30 μM; 3 d) inhibits MDA-MB-231 tumor growth on chick chorioallantoic membranes[2]. Chrysosplenol D (0.07-0.28 mmol/kg) protects against LPS-induced systemic inflammatory response syndrome (SIRS) in mice[4]. Chrysosplenol D (1-1.5 μmol/cm2) inhibits croton oil-induced ear edema in mice[4]. |
| References |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 645.0±55.0 °C at 760 mmHg |
| Molecular Formula | C18H16O8 |
| Molecular Weight | 360.315 |
| Flash Point | 237.3±25.0 °C |
| Exact Mass | 360.084503 |
| PSA | 118.59000 |
| LogP | 2.29 |
| Vapour Pressure | 0.0±2.0 mmHg at 25°C |
| Index of Refraction | 1.680 |
| InChIKey | BYWLLSQTJBXAPV-UHFFFAOYSA-N |
| SMILES | COc1cc2oc(-c3ccc(O)c(O)c3)c(OC)c(=O)c2c(O)c1OC |
| Hazard Codes | Xi |
|---|---|
| HS Code | 2914509090 |
| HS Code | 2914509090 |
|---|---|
| Summary | HS:2914509090 other ketones with other oxygen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0% |
| 5,3',4'-trihydroxy-3,6,7-trimethoxyflavone |
| 3',4',5-Trihydroxy-3,6,7-trimethoxyflavone |
| quercetagetin 3,6,7-trimethylether |
| 4H-1-Benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-5-hydroxy-3,6,7-trimethoxy- |
| 2-(3,4-Dihydroxyphenyl)-5-hydroxy-3,6,7-trimethoxy-4H-chromen-4-one |
| Chrysosplenol D |
| chrysophenol-D |
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- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: Chrysosplenol D
- Price: Check
- Purity: 98.0%
- Delivery: 10 Day
- Contact: Yang
- Email: sales@echemcloud.com
- Shanghai Jizhi Biochemical Technology Co., Ltd
- China
- Product Name: Chrysosplenol D
- Price: ￥4000.0/5mg
- Purity: 98.0%
- Delivery: 3 Day
- Contact: Liu jia
- Email: 2130147988@qq.com
- DC Chemicals Limited
- China
- Product Name: Chrysosplenol D
- Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
- Purity: 98.0%
- Delivery: 3 Day
- Contact: Tony Cao
- Email: sales@dcchemicals.com
- Dayang Chem (Hangzhou) Co., Ltd.
- China
- Product Name: CHRYSOSPLENOL D
- Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
- Purity: 98.0%
- Delivery: Inquiry
- Contact: Ms Wang
- Email: enquiry@dycnchem.com
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