Bexlosteride.
Modify Date: 2024-01-13 18:59:41
Bexlosteride. structure
|
Common Name | Bexlosteride. | ||
|---|---|---|---|---|
| CAS Number | 148905-78-6 | Molecular Weight | 249.736 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 413.9±45.0 °C at 760 mmHg | |
| Molecular Formula | C14H16ClNO | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 204.1±28.7 °C | |
Use of Bexlosteride.Bexlosteride (LY300502) is a benzoquinolinone human type I 5α-reductase inhibitor. Bexlosteride shows metabolic inhibitory, antiproliferative, and antisecretory effects in LNCaP human prostatic adenocarcinoma cell cultures. Bexlosteride can be used for the research of prostatic cancer[1][2]. |
| Name | Bexlosteride |
|---|---|
| Synonym | More Synonyms |
| Description | Bexlosteride (LY300502) is a benzoquinolinone human type I 5α-reductase inhibitor. Bexlosteride shows metabolic inhibitory, antiproliferative, and antisecretory effects in LNCaP human prostatic adenocarcinoma cell cultures. Bexlosteride can be used for the research of prostatic cancer[1][2]. |
|---|---|
| Related Catalog | |
| Target |
human type I 5α-reductase[1] |
| In Vitro | Bexlosteride concentration-dependently inhibits reductive metabolism of [3H-T] in the LNCaP cells, with an IC50 of 5.77 nM[1]. Bexlosteride significantly antagonizes Testosterone-induced stimulation of LNCaP cellular proliferation at concentrations greater than 10 nM, and at 1000 nM completely blocks the mitogenic effects of Testosterone on LNCaP cells[1]. Bexlosteride significantly antagonizes Testosterone -induced PSA secretion at a concentration equal to or greater than 30 nM[1]. |
| References |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 413.9±45.0 °C at 760 mmHg |
| Molecular Formula | C14H16ClNO |
| Molecular Weight | 249.736 |
| Flash Point | 204.1±28.7 °C |
| Exact Mass | 249.092041 |
| LogP | 3.17 |
| Vapour Pressure | 0.0±1.0 mmHg at 25°C |
| Index of Refraction | 1.571 |
| Hazard Codes | Xi |
|---|
| Benzo[f]quinolin-3(2H)-one, 8-chloro-1,4,4a,5,6,10b-hexahydro-4-methyl-, (4aR,10bR)- |
| (4aR,10bR)-8-Chloro-4-methyl-1,4,4a,5,6,10b-hexahydrobenzo[f]quinolin-3(2H)-one |
| 36X732P4P0 |
| bexlostéride |
| (4aR-trans)-8-Chloro-4-methyl-1,4,4a,5,6,10b-hexahydrobenzo[f]quinolin-3(2H)-one |
| Benzo(f)quinolin-3(2H)-one, 8-chloro-1,4,4a,5,6,10b-hexahydro-4-methyl-, trans- |
| Bexlosteride |