| Description |
Pexiganan (MSI 78 free base) is a synthetic analog of magainin 2. Pexiganan is a potent and orally active broad-spectrum antimicrobial peptide. Pexiganan can be used in the research of infections, such as diabetic foot ulcer infections[1].
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| Related Catalog |
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| In Vitro |
Pexiganan (MIC: 0-128 μg/mL approximately) shows broad-spectrum antibacterial activity against 3,109 clinical isolates of gram-positive and gram-negative, anaerobic and aerobic bacteria[2]. Pexiganan (4 μg/mL) inhibits gastric ulcer strain and gastric cancer strain[3].
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| In Vivo |
Pexiganan (1, 3, 10 or 30 mg/kg, p.o., daily for three consecutive days) shows H. pylori clearance efficiency in H. pylori-infected mouse[3]. Pexiganan (1 mg/kg, i.p.) shows antimicrobial activity in rat models of Gram-negative septic shock[4]. Animal Model: H. pylori-infected mouse[3]. Dosage: 1, 3, 10 or 30 mg/kg Administration: Oral administration, daily for three consecutive days. Result: Lowered H. pylori urease activities in mouse stomachs. Animal Model: Rat models of Gram-negative septic shock (induced by E.coli ATCC 25922)[4]. Dosage: 1 mg/kg Administration: Intraperitoneal injection (i.p.) Result: Displayed antimicrobial activities and survival rates of 67.7%.
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