pepticinnamin E

Modify Date: 2025-08-29 03:15:14

pepticinnamin E Structure
pepticinnamin E structure
Common Name pepticinnamin E
CAS Number 147317-36-0 Molecular Weight 908.43400
Density 1.284g/cm3 Boiling Point 1124.3ºC at 760 mmHg
Molecular Formula C49H54ClN5O10 Melting Point N/A
MSDS N/A Flash Point 633.7ºC

 Use of pepticinnamin E


Pepticinnamin E is a Farnesyltransferase (FTase) inhibitor (IC50=42 µM). Pepticinnamin E can be used in cancer and malaria research[1][2].

 Names

Name [(2R)-3,6-dioxopiperazin-2-yl]methyl (2R,4R)-2-benzyl-2-[[(2S)-3-(2-chloro-3-hydroxy-4-methoxyphenyl)-2-(methylamino)propanoyl]-methylamino]-5-(4-hydroxyphenyl)-3-oxo-4-[[(E)-3-[2-[(E)-pent-2-enyl]phenyl]prop-2-enoyl]amino]pentanoate
Synonym More Synonyms

 pepticinnamin E Biological Activity

Description Pepticinnamin E is a Farnesyltransferase (FTase) inhibitor (IC50=42 µM). Pepticinnamin E can be used in cancer and malaria research[1][2].
Related Catalog
Target

IC50: 42 µM (Farnesyltransferase)[1].

References

[1]. Hinterding K, et al. Synthesis and In Vitro Evaluation of the Ras Farnesyltransferase Inhibitor Pepticinnamin E. Angew Chem Int Ed Engl. 1998 May 18;37(9):1236-1239.  

[2]. Santa Maria KC, et al. Targeted Rediscovery and Biosynthesis of the Farnesyl-Transferase Inhibitor Pepticinnamin E. Chembiochem. 2019 Jun 3;20(11):1387-1393.  

 Chemical & Physical Properties

Density 1.284g/cm3
Boiling Point 1124.3ºC at 760 mmHg
Molecular Formula C49H54ClN5O10
Molecular Weight 908.43400
Flash Point 633.7ºC
Exact Mass 907.35600
PSA 223.17000
LogP 5.78970
Vapour Pressure 0mmHg at 25°C
Index of Refraction 1.612

 Synonyms

Pepticinnamin E
Pepticinnamine E
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