Ranirestat

Modify Date: 2025-08-23 22:16:18

Ranirestat structure	Common Name	Ranirestat
	CAS Number	147254-64-6	Molecular Weight	420.18900
	Density	1.83g/cm3	Boiling Point	702.7ºC at 760mmHg
	Molecular Formula	C₁₇H₁₁BrFN₃O₄	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	378.8ºC
	Symbol	GHS07	Signal Word	Warning

Use of Ranirestat

Ranirestat (AS-3201) is an aldose reductase inhibitor being developed for the treatment of diabetic neuropathy.

Name	(3R)-2'-[(4-bromo-2-fluorophenyl)methyl]spiro[pyrrolidine-3,4'-pyrrolo[1,2-a]pyrazine]-1',2,3',5-tetrone
Synonym	More Synonyms

Description	Ranirestat (AS-3201) is an aldose reductase inhibitor being developed for the treatment of diabetic neuropathy.
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Aldose Reductase Research Areas >> Metabolic Disease
References	[1]. Kurono M, et al. Stereospecific recognition of a spirosuccinimide type aldose reductase inhibitor (AS-3201) by plasma proteins: a significant role of specific binding by serum albumin in the improved potency and stability. Biochem Pharmacol. 2006 Jan 12;7 [2]. Matsumoto T, et al. Improvement of motor nerve conduction velocity in diabetic rats requires normalization of the polyol pathway metabolites flux. J Pharmacol Sci. 2009 Feb;109(2):203-10. [3]. Toyoda F, et al. Effect of ranirestat, a new aldose reductase inhibitor, on diabetic retinopathy in SDT rats. J Diabetes Res. 2014;2014:672590.

Description

Ranirestat (AS-3201) is an aldose reductase inhibitor being developed for the treatment of diabetic neuropathy.

Related Catalog

Signaling Pathways >> Metabolic Enzyme/Protease >> Aldose Reductase

Research Areas >> Metabolic Disease

References

[1]. Kurono M, et al. Stereospecific recognition of a spirosuccinimide type aldose reductase inhibitor (AS-3201) by plasma proteins: a significant role of specific binding by serum albumin in the improved potency and stability. Biochem Pharmacol. 2006 Jan 12;7

[2]. Matsumoto T, et al. Improvement of motor nerve conduction velocity in diabetic rats requires normalization of the polyol pathway metabolites flux. J Pharmacol Sci. 2009 Feb;109(2):203-10.

[3]. Toyoda F, et al. Effect of ranirestat, a new aldose reductase inhibitor, on diabetic retinopathy in SDT rats. J Diabetes Res. 2014;2014:672590.

Density	1.83g/cm3
Boiling Point	702.7ºC at 760mmHg
Molecular Formula	C₁₇H₁₁BrFN₃O₄
Molecular Weight	420.18900
Flash Point	378.8ºC
Exact Mass	418.99200
PSA	91.97000
LogP	1.52790
Vapour Pressure	1.36E-19mmHg at 25°C
Index of Refraction	1.749
InChIKey	QCVNMNYRNIMDKV-QGZVFWFLSA-N
SMILES	O=C1CC2(C(=O)N1)C(=O)N(Cc1ccc(Br)cc1F)C(=O)c1cccn12
Storage condition	2-8℃

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P280-P304 + P340 + P312-P305 + P351 + P338-P337 + P313
RIDADR	NONH for all modes of transport
RTECS	WH1441246

4-Bromo-2-fluor...

CAS#:112734-22-2

N/A

CAS#:159213-26-0

~73%

Ranirestat

CAS#:147254-64-6

Literature: Mashiko, Tomoyuki; Hara, Keiichi; Tanaka, Daisuke; Fujiwara, Yuji; Kumagai, Naoya; Shibasaki, Masakatsu Journal of the American Chemical Society, 2007 , vol. 129, # 37 p. 11342 - 11343

Precursor 1
CAS#:112734-22-2 4-Bromo-2-fluor...
DownStream 0

(3R)-2'-(4-bromo-2-fluorobenzyl)spiro[pyrrolidin-3,4'(1'H)-pyrrolo[1,2-a]pyrazin]-1',2,3',5(2'H)-tetraone

Ranirestat

Ranirestat (JAN/INN)

(R)-2-(4-bromo-2-fluorobenzyl)spiro[1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine-4,3'-pyrrolidine]-1,2',3,5'-tetrone

R-(-)-2-(4-bromo-2-fluorobenzyl)-1,2,3,4-tetrahydro[1,2-a]pyrrolopyridine-4-spiro-3'-pyrrolidine-1,2',3'5'-tetraone

SX-3202

(3R)-2'-(4-bromo-2-fluorobenzyl)spiro[pyrrolidine-3,4'(1'H)-pyrrolo[1,2-a]pyrazine]-1',2,3',5(2H')-tetraone

AS-3201

SX 3030

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Ranirestat
Price: Check
Purity: 99.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

ShangHai DC Chemicals Co.,Ltd
China
Product Name: AS-3201
Price: ￥Inquiry/1g
Purity: 98.9%
Delivery: 1 Day
Contact: Tony Lai
Email: order@dcchemicals.com

DC Chemicals Limited
China
Product Name: AS-3201
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

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Price: $343/10mM*1mLinDMSO

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Ranirestat

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Precursor & DownStream

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The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.