diphenylpyraline

Modify Date: 2024-01-08 15:50:22

diphenylpyraline structure	Common Name	diphenylpyraline
	CAS Number	147-20-6	Molecular Weight	281.39200
	Density	1.08 g/cm3	Boiling Point	378.7ºC at 760 mmHg
	Molecular Formula	C₁₉H₂₃NO	Melting Point	N/A
	MSDS	N/A	Flash Point	111.6ºC

Use of diphenylpyraline

Diphenylpyraline is a potent histamine H1 receptor antagonist. Diphenylpyraline acts as an orally active antihistamine agent with antimuscarinic and antiallergic effects. Diphenylpyraline can be used for the research of allergic diseases, including rhinitis and hay fever, and pruritic skin disorders et.al[1].

Name	diphenylpyraline
Synonym	More Synonyms

Description	Diphenylpyraline is a potent histamine H1 receptor antagonist. Diphenylpyraline acts as an orally active antihistamine agent with antimuscarinic and antiallergic effects. Diphenylpyraline can be used for the research of allergic diseases, including rhinitis and hay fever, and pruritic skin disorders et.al[1].
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor Research Areas >> Inflammation/Immunology Signaling Pathways >> GPCR/G Protein >> Histamine Receptor
Target	H1 Receptor
In Vitro	Diphenylpyraline (10 μM) markedly inhibits dopamine uptakein mouse nucleus accumbens slices[2].
In Vivo	Diphenylpyraline (intraperitoneal injection; 5-10 mg/kg) elevates extracellular dopamine levels (~200%) in mouse nucleus accumbens and induces locomotor activation in mice[2]. Animal Model: C57BL/6 mice[2] Dosage: 5-10 mg/kg Administration: Intraperitoneal injection Result: Had psychostimulant properties.
References	[1]. Erik B Oleson, et al. Effects of the histamine H₁ receptor antagonist and benztropine analog diphenylpyraline on dopamine uptake, locomotion and reward. [2]. Gennady B Lapa, et al. Diphenylpyraline, a histamine H1 receptor antagonist, has psychostimulant properties.

Density	1.08 g/cm3
Boiling Point	378.7ºC at 760 mmHg
Molecular Formula	C₁₉H₂₃NO
Molecular Weight	281.39200
Flash Point	111.6ºC
Exact Mass	281.17800
PSA	12.47000
LogP	3.82470
Vapour Pressure	6.18E-06mmHg at 25°C
Index of Refraction	1.587

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TM7810000

CHEMICAL NAME :: Piperidine, 4-(diphenylmethoxy)-1-methyl-

CAS REGISTRY NUMBER :: 147-20-6

BEILSTEIN REFERENCE NO. :: 0245467

LAST UPDATED :: 199612

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C19-H23-N-O

MOLECULAR WEIGHT :: 281.43

WISWESSER LINE NOTATION :: T6NTJ A1 DOYR&R

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 50,459,1979 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 250 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris, France) V.1- 1946- Volume(issue)/page/year: 26,155,1971

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 42 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris, France) V.1- 1946- Volume(issue)/page/year: 26,1203,1971 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84788 No. of Facilities: 21 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 62 (estimated)

Hazard Codes	Xn
RIDADR	UN 3249
Packaging Group	III
Hazard Class	6.1(b)
HS Code	2933399090

Precursor 3
CAS#:106-52-5 1-Methyl-4-pipe... CAS#:776-74-9 Bromodiphenylmethane CAS#:90-99-3 benzhydryl chloride
DownStream 2
CAS#:58258-01-8 4-(Diphenylmeth... CAS#:65214-84-8 ethyl 4-benzhyd...

HS Code	2933399090
Summary	2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Hispril

N-methyl-4-(diphenylmethoxy)piperidine

Neargal

Lergobine

EINECS 205-686-7

Belfene

Dayfen

4-benzhydryloxy-1-methyl-piperidine

Histyn

Mepiben

4-Benzhydryloxy-1-methyl-piperidin

4-Diphenylmethoxy-1-methyl-piperidin

4-(diphenylmethoxy)-1-methylpiperidine

Lyssipoll

Allergen

4-benzhydryloxy-1-methylpiperidine

DC Chemicals Limited
China
Product Name: AN 1041
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: diphenylpyraline
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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