1-Hydroxy Pioglitazone Hydrochloride

Modify Date: 2024-01-02 11:20:23

1-Hydroxy Pioglitazone Hydrochloride structure	Common Name	1-Hydroxy Pioglitazone Hydrochloride
	CAS Number	146062-46-6	Molecular Weight	408.90
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₉H₂₁ClN₂O₄S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of 1-Hydroxy Pioglitazone Hydrochloride

Leriglitazone (Hydroxypioglitazone) hydrochloride, a metabolite of pioglitazone. Leriglitazone (Hydroxypioglitazone) hydrochloride PioOH is a PPARγ agonist, stabilizes the PPARγ activation function-2 (AF-2) co-activator binding surface and enhances co-activator binding, affording slightly better transcriptional efficacy. Leriglitazone (Hydroxypioglitazone) hydrochloride binds to the PPARγ C-terminal ligand-binding domain (LBD) with a Ki of 1.2 μM，Leriglitazone induces transcriptional efficacy of the PPARγ (LBD) with an EC50 of 680 nM[1].

Name	5-(4-{2-[5-(1-Hydroxyethyl)-2-pyridinyl]ethoxy}benzyl)-1,3-thiazolidine-2,4-dione hydrochloride (1:1)
Synonym	More Synonyms

Description	Leriglitazone (Hydroxypioglitazone) hydrochloride, a metabolite of pioglitazone. Leriglitazone (Hydroxypioglitazone) hydrochloride PioOH is a PPARγ agonist, stabilizes the PPARγ activation function-2 (AF-2) co-activator binding surface and enhances co-activator binding, affording slightly better transcriptional efficacy. Leriglitazone (Hydroxypioglitazone) hydrochloride binds to the PPARγ C-terminal ligand-binding domain (LBD) with a Ki of 1.2 μM，Leriglitazone induces transcriptional efficacy of the PPARγ (LBD) with an EC50 of 680 nM[1].
Related Catalog	Signaling Pathways >> Cell Cycle/DNA Damage >> PPAR Research Areas >> Metabolic Disease
Target	PPAR-γ
References	[1]. Mosure SA,et al. Structural Basis of Altered Potency and Efficacy Displayed by a Major in Vivo Metabolite of the Antidiabetic PPARγ Drug Pioglitazone. J Med Chem. 2019 Feb 28;62(4):2008-2023.

Molecular Formula	C₁₉H₂₁ClN₂O₄S
Molecular Weight	408.90
Exact Mass	408.091064

5-(4-{2-[5-(1-Hydroxyethyl)-2-pyridinyl]ethoxy}benzyl)-1,3-thiazolidine-2,4-dione hydrochloride (1:1)

2,4-Thiazolidinedione, 5-[[4-[2-[5-(1-hydroxyethyl)-2-pyridinyl]ethoxy]phenyl]methyl]-, hydrochloride (1:1)

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 1-Hydroxy Pioglitazone Hydrochloride
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

Get all suppliers and price by the below link:

1-Hydroxy Pioglitazone Hydrochloride suppliers

Price: ￥7700/5 mg

Reference only. check more 1-Hydroxy Pioglitazone Hydrochloride price

1-Hydroxy Pioglitazone Hydrochloride

Use of 1-Hydroxy Pioglitazone Hydrochloride

Names

1-Hydroxy Pioglitazone Hydrochloride Biological Activity

Chemical & Physical Properties

Synonyms