Troxacitabine

Modify Date: 2024-01-22 10:50:56

Troxacitabine Structure
Troxacitabine structure
 Common Name Troxacitabine
CAS Number 145918-75-8 Molecular Weight 213.19100
Density 1.71g/cm3 Boiling Point 422.5ºC at 760mmHg
Molecular Formula C8H11N3O4 Melting Point N/A
MSDS N/A Flash Point 209.3ºC

 Use of Troxacitabine


Troxacitabine is nucleoside analog with potent anticancer activity.

 Names

Name 4-amino-1-[(2S,4S)-2-(hydroxymethyl)-1,3-dioxolan-4-yl]pyrimidin-2-one
Synonym More Synonyms

 Troxacitabine Biological Activity

Description Troxacitabine is nucleoside analog with potent anticancer activity.
Related Catalog
In Vitro Troxacitabine has shown cutotoxicity in cancer cell lines of hepatocellular (HepG2), prostate (PC3, DUI45), non-small cell lung (NCI-H460, NCr-322M) colon (HT29), renal (CAK-l, A498, RXF-393, SNI2-C) and pancreatic origin (Pnac-Ol, MiaPa Ca) with IC50s range from 15-35 μM[1][2].
In Vivo Troxacitabine is highly active against the Panc-01 model, with TGI levels of 88.5% and 84.3% at the 10 and 25 mg/kg doses, respectively. The mean final tumor weights for animals given troxacitabine are also significantly smaller compared with vehicle controls. Troxacitabine has less activity against the MiaPaCa model[3]. Troxacitabine is very effective in human RCC tumor xenograft models, including CAM-i, A498, RXF-393, and SN12C carcinomas. Very good responses are ob served in animals bearing CAM-i, A498, and RXF-393 RCC tumors given i.p. doses of 10, 25, and 50 mg/kg twice a day for 5 days[2].
Animal Admin Mice[3] Troxacitabine is administered i.v. to the animals at doses of 10 and 25 mg/kg on a daily 3 5 regimen. Gemcitabine is used as a positive control. The end points for the study included tumor growth inhibition (TGI), final weight, and the number of partial and complete tumor responses in the animals[3].
References

[1]. Gourdeau H, et al. Antitumor activity of troxacitabine (Troxatyl) against anthracycline-resistant human xenografts. Cancer Chemother Pharmacol. 2002 Dec;50(6):490-6.

[2]. Kadhim SA, et al. Potent antitumor activity of a novel nucleoside analogue, BCH-4556 (beta-L-dioxolane-cytidine), in human renal cell carcinoma xenograft tumor models. Cancer Res. 1997 Nov 1;57(21):4803-10.

[3]. Weitman S, et al. The new dioxolane, (-)-2'-deoxy-3'-oxacytidine (BCH-4556, troxacitabine), has activity againstpancreatic human tumor xenografts. Clin Cancer Res. 2000 Apr;6(4):1574-8.

 Chemical & Physical Properties

Density 1.71g/cm3
Boiling Point 422.5ºC at 760mmHg
Molecular Formula C8H11N3O4
Molecular Weight 213.19100
Flash Point 209.3ºC
Exact Mass 213.07500
PSA 99.60000
Vapour Pressure 6.59E-09mmHg at 25°C
Index of Refraction 1.694

 Safety Information

HS Code 2933599090

 Customs

HS Code 2933599090
Summary 2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

S1535_Selleck
Bch-4556
cis-Dioxolane-C
Troxacitabine
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Related Compounds: More...
troxacitabine
141196-85-2
troxacitabine
141196-84-1
Chemsrc provides Troxacitabine(CAS#:145918-75-8) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Troxacitabine are included as well.>> amp version: Troxacitabine

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