Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 4-AMINO-1-((2S,4S)-2-(HYDROXYMETHYL)-1,3-DIOXOLAN-4-YL)PYRIMIDIN-2(1H)-ONE
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Purity: 98.0%
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145918-75-8

145918-75-8 structure

145918-75-8 structure

Name: Troxacitabine
Chemical Name: 4-amino-1-[(2S,4S)-2-(hydroxymethyl)-1,3-dioxolan-4-yl]pyrimidin-2-one
CAS Number: 145918-75-8
Molecular Formula: C₈H₁₁N₃O₄
Molecular Weight: 213.19100
Catalog: Research Areas Cancer
Create Date: 2018-06-17 12:43:42
Modify Date: 2024-01-22 10:50:56
Troxacitabine is nucleoside analog with potent anticancer activity.

Name	4-amino-1-[(2S,4S)-2-(hydroxymethyl)-1,3-dioxolan-4-yl]pyrimidin-2-one
Synonyms	S1535_Selleck Bch-4556 cis-Dioxolane-C Troxacitabine

Description	Troxacitabine is nucleoside analog with potent anticancer activity.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Cancer
In Vitro	Troxacitabine has shown cutotoxicity in cancer cell lines of hepatocellular (HepG2), prostate (PC3, DUI45), non-small cell lung (NCI-H460, NCr-322M) colon (HT29), renal (CAK-l, A498, RXF-393, SNI2-C) and pancreatic origin (Pnac-Ol, MiaPa Ca) with IC50s range from 15-35 μM[1][2].
In Vivo	Troxacitabine is highly active against the Panc-01 model, with TGI levels of 88.5% and 84.3% at the 10 and 25 mg/kg doses, respectively. The mean final tumor weights for animals given troxacitabine are also significantly smaller compared with vehicle controls. Troxacitabine has less activity against the MiaPaCa model[3]. Troxacitabine is very effective in human RCC tumor xenograft models, including CAM-i, A498, RXF-393, and SN12C carcinomas. Very good responses are ob served in animals bearing CAM-i, A498, and RXF-393 RCC tumors given i.p. doses of 10, 25, and 50 mg/kg twice a day for 5 days[2].
Animal Admin	Mice[3] Troxacitabine is administered i.v. to the animals at doses of 10 and 25 mg/kg on a daily 3 5 regimen. Gemcitabine is used as a positive control. The end points for the study included tumor growth inhibition (TGI), final weight, and the number of partial and complete tumor responses in the animals[3].
References	[1]. Gourdeau H, et al. Antitumor activity of troxacitabine (Troxatyl) against anthracycline-resistant human xenografts. Cancer Chemother Pharmacol. 2002 Dec;50(6):490-6. [2]. Kadhim SA, et al. Potent antitumor activity of a novel nucleoside analogue, BCH-4556 (beta-L-dioxolane-cytidine), in human renal cell carcinoma xenograft tumor models. Cancer Res. 1997 Nov 1;57(21):4803-10. [3]. Weitman S, et al. The new dioxolane, (-)-2'-deoxy-3'-oxacytidine (BCH-4556, troxacitabine), has activity againstpancreatic human tumor xenografts. Clin Cancer Res. 2000 Apr;6(4):1574-8.

Density	1.71g/cm3
Boiling Point	422.5ºC at 760mmHg
Molecular Formula	C₈H₁₁N₃O₄
Molecular Weight	213.19100
Flash Point	209.3ºC
Exact Mass	213.07500
PSA	99.60000
Vapour Pressure	6.59E-09mmHg at 25°C
Index of Refraction	1.694

HS Code	2933599090

146996-25-0 structure

146996-25-0

~90%

145918-75-8 structure

145918-75-8

Literature: Kim; Schinazi; Shanmuganathan; Jeong; Beach; Nampalli; Cannon; Chu Journal of Medicinal Chemistry, 1993 , vol. 36, # 5 p. 519 - 528

145414-63-7 structure

145414-63-7

~%

145918-75-8 structure

145918-75-8

Literature: Tetrahedron Letters, , vol. 33, # 46 p. 6899 - 6902

145875-99-6 structure

145875-99-6

~%

145918-75-8 structure

145918-75-8

145416-37-1 structure

145416-37-1

Literature: Tetrahedron Letters, , vol. 33, # 46 p. 6949 - 6952

192581-99-0 structure

192581-99-0

~%

145918-75-8 structure

145918-75-8

145416-37-1 structure

145416-37-1

Literature: Tetrahedron Letters, , vol. 33, # 46 p. 6949 - 6952

HS Code	2933599090
Summary	2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%