TD139

Modify Date: 2024-01-02 17:21:38

TD139 Structure
TD139 structure
Common Name TD139
CAS Number 1450824-22-2 Molecular Weight 648.635
Density 1.8±0.1 g/cm3 Boiling Point 1017.2±75.0 °C at 760 mmHg
Molecular Formula C28H30F2N6O8S Melting Point N/A
MSDS N/A Flash Point 569.0±37.1 °C

 Use of TD139


TD139 is an inhaled galectin-3 inhibitor with a Kd of 14 nM.

 Names

Name TD139
Synonym More Synonyms

 TD139 Biological Activity

Description TD139 is an inhaled galectin-3 inhibitor with a Kd of 14 nM.
Related Catalog
Target

Kd: 14 nM (galectin-3)[1]

In Vitro TD139 is a novel synthetic inhibitor of galectin-3. TD139 has high affinity for galectin-3 with a Kd of 14 nM and 10 nM for galectin-1, but low affinity for galectins 2, 4N, 4C, 7, 8N, or 9N[1].
In Vivo In primary lung AECs TD139 reduces TGF-β1–induced β-catenin translocation to the nucleus, with most of the β-catenin remaining at the cell surface. TD139 blocks TGF-β1–induced β-catenin phosphorylation. A marked reduction in fibrosis and β-catenin activation accompanied by decreased galectin-3 expression is observed in the lungs of WT mice treated with TD139[1]. Pretreatment of WT C57BL/6 mice with TD139 leads to the attenuation of liver injury and milder infiltration of IFNγ- and IL-17- and -4-producing CD4(+) T cells, as well as an increase in the total number of IL-10-producing CD4(+) T cells and F4/80(+) CD206(+) alternatively activates macrophages and preventes the apoptosis of liver-infiltrating MNCs[2].
Animal Admin Mice: The susceptibility to Con A-induced hepatitis in galectin-3-deficient mice is tested and the effects of pretreatment with a selective inhibitor of Gal-3 (TD139) in wild-type(WT) C57BL/6 mice are analyzed, as evaluated by a liver enzyme test, quantitative histology, mononuclear cell (MNC) infiltration, cytokine production, intracellular staining of immune cells, and percentage of apoptotic MNCs in the liver[2].
References

[1]. Mackinnon AC, et al. Regulation of transforming growth factor-β1-driven lung fibrosis by galectin-3. Am J Respir Crit Care Med. 2012 Mar 1;185(5):537-46.

[2]. Volarevic V, et al. Galectin-3 deficiency prevents concanavalin A-induced hepatitis in mice. Hepatology. 2012 Jun;55(6):1954-64.

 Chemical & Physical Properties

Density 1.8±0.1 g/cm3
Boiling Point 1017.2±75.0 °C at 760 mmHg
Molecular Formula C28H30F2N6O8S
Molecular Weight 648.635
Flash Point 569.0±37.1 °C
Exact Mass 648.181396
LogP 2.19
Vapour Pressure 0.0±0.3 mmHg at 25°C
Index of Refraction 1.761

 Synonyms

TD-139
β-D-Galactopyranoside, 3-deoxy-3-[4-(3-fluorophenyl)-1H-1,2,3-triazol-1-yl]-β-D-galactopyranosyl 3-deoxy-3-[4-(3-fluorophenyl)-1H-1,2,3-triazol-1-yl]-1-thio-
60Y0GUO72B
3-Deoxy-3-[4-(3-fluorophenyl)-1H-1,2,3-triazol-1-yl]-β-D-galactopyranosyl 3-deoxy-3-[4-(3-fluorophenyl)-1H-1,2,3-triazol-1-yl]-1-thio-β-D-galactopyranoside
Top Suppliers:I want be here
  • DC Chemicals Limited
  • China
  • Product Name: TD139
  • Price: $900.0/100mg $1500.0/250mg $3100.0/1g
  • Purity: 98.0%
  • Stocking Period: 3 Day
  • Contact: Tony Cao

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Price: $80/1mg

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