AZ82
Modify Date: 2024-01-20 14:05:39
AZ82 structure
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Common Name | AZ82 | ||
|---|---|---|---|---|
| CAS Number | 1449578-65-7 | Molecular Weight | 560.63 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C28H31F3N4O3S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of AZ82AZ82 is a selective HSET/KIFC1 inhibitor, with a Ki of 43 nM and an IC50 of 300 nM for KIFC1. |
| Name | AZ82 |
|---|
| Description | AZ82 is a selective HSET/KIFC1 inhibitor, with a Ki of 43 nM and an IC50 of 300 nM for KIFC1. |
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| Related Catalog | |
| Target |
HSET/KIFC1:300 nM (IC50) HSET/KIFC1:43 nM (Ki) |
| In Vitro | AZ82 is shown to specifically induce multipolar spindles in BT-549 cells, but not in cancer cells with normal centrosome number, such as HeLa[1]. AZ82 binds specifically to KIFC1/MT complex but not to KIFC1 or MT alone. Treatment with AZ82 caused centrosome declustering in BT-549 breast cancer cells with amplified centrosomes. AZ82 inhibits both processes with an IC50 of 0.90 ± 0.09 μM for mant-ATP binding and 1.26 ± 0.51 μM for mant-ADP releasing[2]. |
| References |
| Molecular Formula | C28H31F3N4O3S |
|---|---|
| Molecular Weight | 560.63 |
| Storage condition | 2-8℃ |