Eleclazine hydrochloride
Modify Date: 2025-08-26 14:20:48
Eleclazine hydrochloride structure
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Common Name | Eleclazine hydrochloride | ||
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| CAS Number | 1448754-43-5 | Molecular Weight | 451.826 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C21H17ClF3N3O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Eleclazine hydrochlorideEleclazine hydrochloride is a novel late Na+ current inhibitor with IC50 value of 0.7 uM. target: Na+ current.IC50: 0.7 uM.In vitro: Eleclazine hydrochloride inhibits ATX-II enhanced late INa in ventricular myocytes, shorten the ATX-II induced prolongation of APD, MAPD, QT interval, and decreased spatiotemporal dispersion of repolarization and ventricular arrhythmias. Inhibition by GS-6615 of ATX-II enhanced late INa is strongly correlated with shortening of myocyte APD and isolated heart MAPD[1]. Selective inhibition of cardiac late INa with eleclazine hydrochloride confers dual protection against vulnerability to ischemia-induced AF and reduces atrial and ventricular repolarization abnormalities before and during adrenergic stimulation without negative inotropic effects. [2] |
| Name | Eleclazine hydrochloride |
|---|---|
| Synonym | More Synonyms |
| Description | Eleclazine hydrochloride is a novel late Na+ current inhibitor with IC50 value of 0.7 uM. target: Na+ current.IC50: 0.7 uM.In vitro: Eleclazine hydrochloride inhibits ATX-II enhanced late INa in ventricular myocytes, shorten the ATX-II induced prolongation of APD, MAPD, QT interval, and decreased spatiotemporal dispersion of repolarization and ventricular arrhythmias. Inhibition by GS-6615 of ATX-II enhanced late INa is strongly correlated with shortening of myocyte APD and isolated heart MAPD[1]. Selective inhibition of cardiac late INa with eleclazine hydrochloride confers dual protection against vulnerability to ischemia-induced AF and reduces atrial and ventricular repolarization abnormalities before and during adrenergic stimulation without negative inotropic effects. [2] |
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| Related Catalog | |
| References |
| Molecular Formula | C21H17ClF3N3O3 |
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| Molecular Weight | 451.826 |
| Exact Mass | 451.091064 |
| Storage condition | 2-8℃ |
| 1,4-Benzoxazepin-5(2H)-one, 3,4-dihydro-4-(2-pyrimidinylmethyl)-7-[4-(trifluoromethoxy)phenyl]-, hydrochloride (1:1) |
| 4-(2-Pyrimidinylmethyl)-7-[4-(trifluoromethoxy)phenyl]-3,4-dihydro-1,4-benzoxazepin-5(2H)-one hydrochloride (1:1) |
| 4R1JP3Q4HI |
| ELECLAZINE HYDROCHLORIDE |
| Eleclazine (hydrochloride) |