HL23

Modify Date: 2024-09-23 12:17:34

HL23 structure	Common Name	HL23
	CAS Number	1448355-15-4	Molecular Weight	712.83
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₄₄H₄₄N₂O₇	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of HL23

HL23 is a histone deacetylase (HDAC) inhibitor with activity against hepatocellular carcinoma (HCC). HL23 enhances acetylation of the TXNIP promoter and upregulates TXNIP expression, thereby mediating potassium channel activity and triggering TXNIP-dependent potassium deprivation. HL23 inhibits HCC progression and metastasis and has a synergistic effect with Sorafenib (HY-10201) and is more potent than Sorafenib+Vorinostat (HY-10221)[1].

Name	HL23

Description	HL23 is a histone deacetylase (HDAC) inhibitor with activity against hepatocellular carcinoma (HCC). HL23 enhances acetylation of the TXNIP promoter and upregulates TXNIP expression, thereby mediating potassium channel activity and triggering TXNIP-dependent potassium deprivation. HL23 inhibits HCC progression and metastasis and has a synergistic effect with Sorafenib (HY-10201) and is more potent than Sorafenib+Vorinostat (HY-10221)[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others Signaling Pathways >> Cell Cycle/DNA Damage >> HDAC Signaling Pathways >> Epigenetics >> HDAC
References	[1]. Lu Y, et al. Thioredoxin-interacting protein-activated intracellular potassium deprivation mediates the anti-tumour effect of a novel histone acetylation inhibitor HL23, a fangchinoline derivative, in human hepatocellular carcinoma. J Adv Res. 2023 Sep;51:181-196.. .

Molecular Formula	C₄₄H₄₄N₂O₇
Molecular Weight	712.83

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HL23

Use of HL23

Names

HL23 Biological Activity

Chemical & Physical Properties