Albendazole sulfone-D3

Modify Date: 2024-01-07 07:02:01

Albendazole sulfone-D3 Structure
Albendazole sulfone-D3 structure
Common Name Albendazole sulfone-D3
CAS Number 1448345-60-5 Molecular Weight 300.349
Density 1.4±0.1 g/cm3 Boiling Point N/A
Molecular Formula C12H12D3N3O4S Melting Point N/A
MSDS Chinese USA Flash Point N/A
Symbol GHS07
GHS07
Signal Word Warning

 Use of Albendazole sulfone-D3


Albendazole sulfone-d3 is the deuterium labeled Albendazole sulfone. Albendazole sulfone is a metabolite of Albendazole, and exhibits anti-parasite effect against Echinococcus multilocularis Metacestodes.

 Names

Name (2H3)Methyl [5-(propylsulfonyl)-1H-benzimidazol-2-yl]carbamate
Synonym More Synonyms

 Albendazole sulfone-D3 Biological Activity

Description Albendazole sulfone-d3 is the deuterium labeled Albendazole sulfone. Albendazole sulfone is a metabolite of Albendazole, and exhibits anti-parasite effect against Echinococcus multilocularis Metacestodes.
Related Catalog
In Vitro Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-223.

[2]. Ingold K, et, al. Efficacies of albendazole sulfoxide and albendazole sulfone against In vitro-cultivated Echinococcus multilocularis metacestodes. Antimicrob Agents Chemother. 1999 May;43(5):1052-61.

[3]. Adas G, et, al. Use of albendazole sulfoxide, albendazole sulfone, and combined solutions as scolicidal agents on hydatid cysts (in vitro study). World J Gastroenterol. 2009 Jan 7;15(1):112-6.

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Molecular Formula C12H12D3N3O4S
Molecular Weight 300.349
Exact Mass 300.097168
LogP 0.86
Index of Refraction 1.620

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302-H317
Precautionary Statements P280-P301 + P312 + P330
Hazard Codes Xn
Risk Phrases 22-43
Safety Phrases 36/37
RIDADR NONH for all modes of transport

 Synonyms

Carbamic acid, N-[5-(propylsulfonyl)-1H-benzimidazol-2-yl]-, methyl-d3 ester
(2H3)Methyl [5-(propylsulfonyl)-1H-benzimidazol-2-yl]carbamate