S-methyl-KE-298

Modify Date: 2025-08-25 17:10:14

S-methyl-KE-298 structure	Common Name	S-methyl-KE-298
	CAS Number	143584-75-2	Molecular Weight	252.329
	Density	1.2±0.1 g/cm3	Boiling Point	457.2±45.0 °C at 760 mmHg
	Molecular Formula	C₁₃H₁₆O₃S	Melting Point	N/A
	MSDS	N/A	Flash Point	230.3±28.7 °C

Use of S-methyl-KE-298

S-methyl-KE-298 is an active metabolite of KE-298. KE-298 inhibits matrix metalloproteinase (MMP-1) production from rheumatoid arthritis (RA) synovial cells.

Name	S-methyl-KE-298
Synonym	More Synonyms

Description	S-methyl-KE-298 is an active metabolite of KE-298. KE-298 inhibits matrix metalloproteinase (MMP-1) production from rheumatoid arthritis (RA) synovial cells.
Related Catalog	Research Areas >> Inflammation/Immunology
In Vitro	S-methyl-KE-298 is a methyl conjugate of deacetyl-KE-298 is plasma[1]. In vitro protein binding of KE-298 and its plasma metabolites, deacetyl-KE-298 (M-1) and S-methyl-KE-298 (M-2), is high in rat (>97%), dog (>89%) and human plasma (>99%), respectively[2]. KE-298 blocks this IL-1β-induced pro-MMP-2 activation and MT1-MMP expression, but does not affect IL-1β-induced tissue inhibitor of metalloproteinase-2 (TIMP-2) secretion from rheumatoid synovial cells. KE-298 inhibits MMP-1 production from rheumatoid arthritis (RA) synovial cells by affecting a transcription factor, AP-1. KE-298 inhibits the basal levels of MT1-MMP expression of unstimulated rheumatoid synovial cells[3].
References	[1]. Yoshida H, et al. Identification of metabolites of KE-298, a new antirheumatic drug, and its physiological properties in rats. Biol Pharm Bull. 1996 Mar;19(3):424-9. [2]. Endo H, et al. Stereoselectivity and species difference in plasma protein binding of KE-298 and its metabolites. Biol Pharm Bull. 2001 Jul;24(7):800-5. [3]. Honda S, et al. Expression of membrane-type 1 matrix metalloproteinase in rheumatoid synovial cells. Clin Exp Immunol. 2001 Oct;126(1):131-6.

Density	1.2±0.1 g/cm3
Boiling Point	457.2±45.0 °C at 760 mmHg
Molecular Formula	C₁₃H₁₆O₃S
Molecular Weight	252.329
Flash Point	230.3±28.7 °C
Exact Mass	252.082016
LogP	2.84
Vapour Pressure	0.0±1.2 mmHg at 25°C
Index of Refraction	1.565
Storage condition	2-8℃

Benzenebutanoic acid, 4-methyl-α-[(methylthio)methyl]-γ-oxo-

4-(4-Methylphenyl)-2-[(methylsulfanyl)methyl]-4-oxobutanoic acid

4-(4-methylphenyl)-2-methylthiomethyl-4-oxobutanoic acid

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China
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: S-methyl-KE-298
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Delivery: Inquiry
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S-methyl-KE-298

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