Isosilybin A

Modify Date: 2024-01-02 15:33:20

Isosilybin A structure	Common Name	Isosilybin A
	CAS Number	142796-21-2	Molecular Weight	482.43600
	Density	1.527±0.06 g/cm3	Boiling Point	793.0±60.0 °C(Predicted)
	Molecular Formula	C₂₅H₂₂O₁₀	Melting Point	201-203 ºC (methanol water )
	MSDS	Chinese USA	Flash Point	N/A

Use of Isosilybin A

Isosilybin A, a flavonolignan isolated from silymarin, has anti-prostate cancer (PCA) activity. Isosilybin A inhibits proliferation and induces G1 phase arrest and apoptosis in cancer cells, which activates apoptotic machinery in PCA cells via targeting Akt-NF-κB-androgen receptor (AR) axis[1][2].

Name	(2R,3R)-3,5,7-trihydroxy-2-[(2R,3R)-2-(4-hydroxy-3-methoxyphenyl)-3-(hydroxymethyl)-2,3-dihydro-1,4-benzodioxin-6-yl]-2,3-dihydrochromen-4-one
Synonym	More Synonyms

Description	Isosilybin A, a flavonolignan isolated from silymarin, has anti-prostate cancer (PCA) activity. Isosilybin A inhibits proliferation and induces G1 phase arrest and apoptosis in cancer cells, which activates apoptotic machinery in PCA cells via targeting Akt-NF-κB-androgen receptor (AR) axis[1][2].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer
References	[1]. Deep G, et al. Isosilybin B and isosilybin A inhibit growth, induce G1 arrest and cause apoptosis in human prostatecancer LNCaP and 22Rv1 cells. Carcinogenesis. 2007 Jul;28(7):1533-42. [2]. Deep G, et al. Isosilybin A induces apoptosis in human prostate cancer cells via targeting Akt, NF-κB, and androgen receptor signaling. Mol Carcinog. 2010 Oct;49(10):902-12.

Description

Related Catalog

Signaling Pathways >> Apoptosis >> Apoptosis

Research Areas >> Cancer

References

[1]. Deep G, et al. Isosilybin B and isosilybin A inhibit growth, induce G1 arrest and cause apoptosis in human prostatecancer LNCaP and 22Rv1 cells. Carcinogenesis. 2007 Jul;28(7):1533-42.

[2]. Deep G, et al. Isosilybin A induces apoptosis in human prostate cancer cells via targeting Akt, NF-κB, and androgen receptor signaling. Mol Carcinog. 2010 Oct;49(10):902-12.

Density	1.527±0.06 g/cm3
Boiling Point	793.0±60.0 °C(Predicted)
Melting Point	201-203 ºC (methanol water )
Molecular Formula	C₂₅H₂₂O₁₀
Molecular Weight	482.43600
Exact Mass	482.12100
PSA	155.14000
LogP	2.36270
Water Solubility	Insuluble (1.1E-3 g/L) (25 ºC)

Isosilybin A MSDS(Chinese)

RIDADR	NONH for all modes of transport

Isosilybin A

Silybin b2

Isosilybin A

Use of Isosilybin A

Names

Isosilybin A Biological Activity

Chemical & Physical Properties

MSDS

Safety Information

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