Isosilybin A

Names

[ Name ]:
Isosilybin A

[Synonym ]:
Isosilybin A
Silybin b2

Biological Activity

[Description]:

Isosilybin A, a flavonolignan isolated from silymarin, has anti-prostate cancer (PCA) activity. Isosilybin A inhibits proliferation and induces G1 phase arrest and apoptosis in cancer cells, which activates apoptotic machinery in PCA cells via targeting Akt-NF-κB-androgen receptor (AR) axis[1][2].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis

Research Areas >> Cancer

[References]

[1]. Deep G, et al. Isosilybin B and isosilybin A inhibit growth, induce G1 arrest and cause apoptosis in human prostatecancer LNCaP and 22Rv1 cells. Carcinogenesis. 2007 Jul;28(7):1533-42.

[2]. Deep G, et al. Isosilybin A induces apoptosis in human prostate cancer cells via targeting Akt, NF-κB, and androgen receptor signaling. Mol Carcinog. 2010 Oct;49(10):902-12.

Chemical & Physical Properties

[ Density]:
1.527±0.06 g/cm3

[ Boiling Point ]:
793.0±60.0 °C(Predicted)

[ Melting Point ]:
201-203 ºC (methanol water )

[ Molecular Formula ]:
C₂₅H₂₂O₁₀

[ Molecular Weight ]:
482.43600

[ Exact Mass ]:
482.12100

[ PSA ]:
155.14000

[ LogP ]:
2.36270

[ Water Solubility ]:
Insuluble (1.1E-3 g/L) (25 ºC)

MSDS

Click to get detail MSDS

Safety Information

[ RIDADR ]:
NONH for all modes of transport