ML299
Modify Date: 2024-04-05 20:49:55
ML299 structure
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Common Name | ML299 | ||
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| CAS Number | 1426916-00-8 | Molecular Weight | 489.380 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 708.8±60.0 °C at 760 mmHg | |
| Molecular Formula | C23H26BrFN4O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 382.5±32.9 °C | |
Use of ML299ML299 is a potent, CNS penetrant, dual phospholipase PLD1/PLD2 probe with IC50 of 6 nM/20 nM, respectively; robustly increases caspase 3/7 activation under serum-free conditions, provides a dose-dependent decrease (100 nM to 10 uM) in invasive migration in U87-MG cells, with statistical significance reached at both the 1 uM and 10 uM doses. |
| Name | 4-Bromo-N-{(2S)-1-[1-(3-fluorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]dec-8-yl]-2-propanyl}benzamide |
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| Synonym | More Synonyms |
| Description | ML299 is a potent, CNS penetrant, dual phospholipase PLD1/PLD2 probe with IC50 of 6 nM/20 nM, respectively; robustly increases caspase 3/7 activation under serum-free conditions, provides a dose-dependent decrease (100 nM to 10 uM) in invasive migration in U87-MG cells, with statistical significance reached at both the 1 uM and 10 uM doses. |
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| References | References 1. Scott SA, et al. Nat Chem Biol. 2009 Feb;5(2):108-17. 2. O'Reilly MC, et al. J Med Chem. 2013 Mar 28;56(6):2695-9. 3. Scott SA, et al. Probe Reports from the NIH Molecular Libraries Program [Internet]. View Related Products by Target Phospholipase |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 708.8±60.0 °C at 760 mmHg |
| Molecular Formula | C23H26BrFN4O2 |
| Molecular Weight | 489.380 |
| Flash Point | 382.5±32.9 °C |
| Exact Mass | 488.122314 |
| LogP | 2.04 |
| Vapour Pressure | 0.0±2.3 mmHg at 25°C |
| Index of Refraction | 1.652 |
| InChIKey | RFKXAYJUFUZBMA-INIZCTEOSA-N |
| SMILES | CC(CN1CCC2(CC1)C(=O)NCN2c1cccc(F)c1)NC(=O)c1ccc(Br)cc1 |
| Benzamide, 4-bromo-N-[(1S)-2-[1-(3-fluorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]dec-8-yl]-1-methylethyl]- |
| 4-Bromo-N-{(2S)-1-[1-(3-fluorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]dec-8-yl]-2-propanyl}benzamide |