ML299

Names

[ Name ]:
ML299

[Synonym ]:
Benzamide, 4-bromo-N-[(1S)-2-[1-(3-fluorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]dec-8-yl]-1-methylethyl]-
4-Bromo-N-{(2S)-1-[1-(3-fluorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]dec-8-yl]-2-propanyl}benzamide

Biological Activity

[Description]:

ML299 is a potent, CNS penetrant, dual phospholipase PLD1/PLD2 probe with IC50 of 6 nM/20 nM, respectively; robustly increases caspase 3/7 activation under serum-free conditions, provides a dose-dependent decrease (100 nM to 10 uM) in invasive migration in U87-MG cells, with statistical significance reached at both the 1 uM and 10 uM doses.

[References]

References 1. Scott SA, et al. Nat Chem Biol. 2009 Feb;5(2):108-17. 2. O'Reilly MC, et al. J Med Chem. 2013 Mar 28;56(6):2695-9. 3. Scott SA, et al. Probe Reports from the NIH Molecular Libraries Program [Internet]. View Related Products by Target Phospholipase

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
708.8±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₃H₂₆BrFN₄O₂

[ Molecular Weight ]:
489.380

[ Flash Point ]:
382.5±32.9 °C

[ Exact Mass ]:
488.122314

[ LogP ]:
2.04

[ Vapour Pressure ]:
0.0±2.3 mmHg at 25°C

[ Index of Refraction ]:
1.652

Related Compounds

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