Parsaclisib
Modify Date: 2025-10-05 19:20:01
Parsaclisib structure
|
Common Name | Parsaclisib | ||
|---|---|---|---|---|
| CAS Number | 1426698-88-5 | Molecular Weight | 432.879 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 650.9±55.0 °C at 760 mmHg | |
| Molecular Formula | C20H22ClFN6O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 347.5±31.5 °C | |
Use of ParsaclisibParsaclisib is a potent and selective PI3Kδ inhibitor, with an IC50 of 1 nM at 1 mM ATP, and shows appr 20,000-fold selectivity for PI3Kα, PI3Kβ, PI3Kγ and 57 other kinases. |
| Name | parsaclisib |
|---|---|
| Synonym | More Synonyms |
| Description | Parsaclisib is a potent and selective PI3Kδ inhibitor, with an IC50 of 1 nM at 1 mM ATP, and shows appr 20,000-fold selectivity for PI3Kα, PI3Kβ, PI3Kγ and 57 other kinases. |
|---|---|
| Related Catalog | |
| Target |
IC50: 1 nM (PI3Kδ, 1 mM ATP)[1] |
| In Vitro | Parsaclisib (INCB050465) is a potent and selective PI3Kδ with an IC50 of 1 nM at 1 mM ATP, and shows appr 20,000-fold selectivity for PI3Kα, PI3Kβ, PI3Kγ and 57 other kinases. Parsaclisib displays significant activity with IC50 values ranging from 0.2 to 2 nM in B and T cell proliferation aaasys. Parsaclisib inhibits proliferation of several DLBCL and MCL cell lines in vitro (EC50 < 10 nM)[1]. |
| References |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 650.9±55.0 °C at 760 mmHg |
| Molecular Formula | C20H22ClFN6O2 |
| Molecular Weight | 432.879 |
| Flash Point | 347.5±31.5 °C |
| Exact Mass | 432.147675 |
| LogP | 1.36 |
| Vapour Pressure | 0.0±1.9 mmHg at 25°C |
| Index of Refraction | 1.704 |
| InChIKey | ZQPDJCIXJHUERQ-QWRGUYRKSA-N |
| SMILES | CCOc1c(C(C)n2nc(C)c3c(N)ncnc32)cc(Cl)c(F)c1C1CNC(=O)C1 |
| Storage condition | 2-8℃ |
| 2-Pyrrolidinone, 4-[3-[(1S)-1-(4-amino-3-methyl-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl]-5-chloro-2-ethoxy-6-fluorophenyl]-, (4R)- |
| parsaclisib |
| OS7097575K |
| (4R)-4-{3-[(1S)-1-(4-Amino-3-methyl-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl]-5-chloro-2-ethoxy-6-fluorophenyl}-2-pyrrolidinone |