CYD-2-11
Modify Date: 2025-09-10 11:15:40
CYD-2-11 structure
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Common Name | CYD-2-11 | ||
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| CAS Number | 1425944-22-4 | Molecular Weight | 358.397 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C22H18N2O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of CYD-2-11CYD-2-11 is a novel potent, selective Bax agonist that targets the structural pocket proximal to S184 in the C-terminal region of Bax (Ki=34.1 nM); shows no affinity for other Bcl-2 family members; directly activates Bax proapoptotic activity by inducing a conformational change enabling formation of Bax homooligomers in mitochondrial membranes; suppresses malignant growth without evident significant toxicity to normal tissues in mutant KRAS-driven lung cancer models; displays strong synergistic activity and overcomes rapalog resistance combined with RAD001. |
| Name | CYD-2-11 |
|---|
| Description | CYD-2-11 is a novel potent, selective Bax agonist that targets the structural pocket proximal to S184 in the C-terminal region of Bax (Ki=34.1 nM); shows no affinity for other Bcl-2 family members; directly activates Bax proapoptotic activity by inducing a conformational change enabling formation of Bax homooligomers in mitochondrial membranes; suppresses malignant growth without evident significant toxicity to normal tissues in mutant KRAS-driven lung cancer models; displays strong synergistic activity and overcomes rapalog resistance combined with RAD001. |
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| References | References 1. Li R, et al. Cancer Res. 2017 Jun 1;77(11):3001-3012. View Related Products by Target Bcl-2 |
| Molecular Formula | C22H18N2O3 |
|---|---|
| Molecular Weight | 358.397 |