1425944-22-4
1425944-22-4 structure
- Name: CYD-2-11
- Chemical Name: CYD-2-11
- CAS Number: 1425944-22-4
- Molecular Formula: C22H18N2O3
- Molecular Weight: 358.397
- Catalog: Signaling Pathways Apoptosis Apoptosis
- Create Date: 2020-01-11 08:42:55
- Modify Date: 2024-04-08 18:53:46
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CYD-2-11 is a novel potent, selective Bax agonist that targets the structural pocket proximal to S184 in the C-terminal region of Bax (Ki=34.1 nM); shows no affinity for other Bcl-2 family members; directly activates Bax proapoptotic activity by inducing a conformational change enabling formation of Bax homooligomers in mitochondrial membranes; suppresses malignant growth without evident significant toxicity to normal tissues in mutant KRAS-driven lung cancer models; displays strong synergistic activity and overcomes rapalog resistance combined with RAD001.
| Name | CYD-2-11 |
|---|
| Description | CYD-2-11 is a novel potent, selective Bax agonist that targets the structural pocket proximal to S184 in the C-terminal region of Bax (Ki=34.1 nM); shows no affinity for other Bcl-2 family members; directly activates Bax proapoptotic activity by inducing a conformational change enabling formation of Bax homooligomers in mitochondrial membranes; suppresses malignant growth without evident significant toxicity to normal tissues in mutant KRAS-driven lung cancer models; displays strong synergistic activity and overcomes rapalog resistance combined with RAD001. |
|---|---|
| References | References 1. Li R, et al. Cancer Res. 2017 Jun 1;77(11):3001-3012. View Related Products by Target Bcl-2 |
| Molecular Formula | C22H18N2O3 |
|---|---|
| Molecular Weight | 358.397 |