Luvadaxistat

Modify Date: 2025-08-25 14:47:52

Use of Luvadaxistat

TAK-831 is a highly selective and potent inhibitor of D-amino acid oxidase (DAAO) and can be used in studies of schizophrenia[1][2].

Name	4-Hydroxy-6-{2-[4-(trifluoromethyl)phenyl]ethyl}-3(2H)-pyridazinone
Synonym	More Synonyms

Description	TAK-831 is a highly selective and potent inhibitor of D-amino acid oxidase (DAAO) and can be used in studies of schizophrenia[1][2].
Related Catalog	Research Areas >> Others Signaling Pathways >> Others >> Others
References	[1]. Wang H, Norton J, Xu L, DeMartinis N, Sen R, Shah A, Farmer J, Lynch D. Results of a randomized double-blind study evaluating luvadaxistat in adults with Friedreich ataxia. Ann Clin Transl Neurol. 2021 Jun;8(6):1343-1352. [2]. Yoneyama T, Sato S, Sykes A, Fradley R, Stafford S, Bechar S, Howley E, Patel T, Tagawa Y, Moriwaki T, Asahi S. Mechanistic Multilayer Quantitative Model for Nonlinear Pharmacokinetics, Target Occupancy and Pharmacodynamics (PK/TO/PD) Relationship of D-Amino Acid Oxidase Inhibitor, TAK-831 in Mice. Pharm Res. 2020 Aug 5;37(8):164.

Description

TAK-831 is a highly selective and potent inhibitor of D-amino acid oxidase (DAAO) and can be used in studies of schizophrenia[1][2].

Related Catalog

Research Areas >> Others

Signaling Pathways >> Others >> Others

References

Density	1.4±0.1 g/cm3
Molecular Formula	C₁₃H₁₁F₃N₂O₂
Molecular Weight	284.23
Exact Mass	284.077271
LogP	1.76
Index of Refraction	1.557
InChIKey	QBQMUMMSYHUDFM-UHFFFAOYSA-N
SMILES	O=c1cc(CCc2ccc(C(F)(F)F)cc2)[nH][nH]c1=O

4-Hydroxy-6-{2-[4-(trifluoromethyl)phenyl]ethyl}-3(2H)-pyridazinone

3(2H)-Pyridazinone, 4-hydroxy-6-[2-[4-(trifluoromethyl)phenyl]ethyl]-

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