(Rac)-BI 703704
Modify Date: 2025-08-23 10:57:13
(Rac)-BI 703704 structure
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Common Name | (Rac)-BI 703704 | ||
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| CAS Number | 1423067-48-4 | Molecular Weight | 559.725 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C32H37N3O4S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of (Rac)-BI 703704A novel potent soluble guanylate cyclase (sGC) activator; reduces progression of renal damage in the ZSF1 rat, shows the potential as an effective therapy for diabetic nephropathy. |
| Name | BI 703704 |
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| Description | A novel potent soluble guanylate cyclase (sGC) activator; reduces progression of renal damage in the ZSF1 rat, shows the potential as an effective therapy for diabetic nephropathy. |
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| Related Catalog | |
| In Vivo | (Rac)-BI 703704 (0.3-10 mg/kg; food intake; daily for 15 weeks) inhibits the progression of diabetic nephropathy in the ZSF1 rat[1]. Animal Model: 12-13 weeks male ZSF1 obese rats[1] Dosage: 0.3, 1, 3, or 10 mg/kg Administration: Food intake; daily for 15 weeks Result: Dose-dependent increased in renal cGMP levels; Dosedependent decreased in urinary protein excretion (UPE); Accompanied by a significant reduction in the incidence of glomerulosclerosis and interstitial lesions. |
| References |
| Molecular Formula | C32H37N3O4S |
|---|---|
| Molecular Weight | 559.725 |
| InChIKey | LRGRKWVKESEOGZ-UHFFFAOYSA-N |
| SMILES | Cc1ccc(OCc2ccc(C(=O)N3CCCCC3)cc2C)c(-c2csc(N3CC4CCC(C3)C4C(=O)O)n2)c1 |