(Rac)-BI 703704

A novel potent soluble guanylate cyclase (sGC) activator; reduces progression of renal damage in the ZSF1 rat, shows the potential as an effective therapy for diabetic nephropathy.

Research Areas >> Metabolic Disease

Signaling Pathways >> GPCR/G Protein >> Guanylate Cyclase

(Rac)-BI 703704 (0.3-10 mg/kg; food intake; daily for 15 weeks) inhibits the progression of diabetic nephropathy in the ZSF1 rat[1]. Animal Model: 12-13 weeks male ZSF1 obese rats[1] Dosage: 0.3, 1, 3, or 10 mg/kg Administration: Food intake; daily for 15 weeks Result: Dose-dependent increased in renal cGMP levels; Dosedependent decreased in urinary protein excretion (UPE); Accompanied by a significant reduction in the incidence of glomerulosclerosis and interstitial lesions.

[1]. Yu L, et al. Picrocrocin exhibits growth inhibitory effects against SKMEL- 2 human malignant melanoma cells by targeting JAK/ STAT5 signaling pathway, cell cycle arrest and mitochondrial mediated apoptosis. J BUON. 2018 Jul-Aug;23(4):1163-1168.