T-3775440
Modify Date: 2025-08-26 17:54:24
T-3775440 structure
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Common Name | T-3775440 | ||
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| CAS Number | 1422620-34-5 | Molecular Weight | 310.401 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C18H22N4O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of T-3775440T-3775440 is a novel potent, selecitve, irreversible LSD1 inhibitor with IC50 of 2.1 nM; displays high selectivity for LSD1 relative to other monoamine oxidases (e.g., MAO-A and MAO-B); disrupts the interaction between LSD1 and growth factor-independent 1B (GFI1B) in leukemia cell lines, exhibites significant antitumor efficacy in AEL and AMKL xenograft models. |
| Name | T-3775440 |
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| Description | T-3775440 is a novel potent, selecitve, irreversible LSD1 inhibitor with IC50 of 2.1 nM; displays high selectivity for LSD1 relative to other monoamine oxidases (e.g., MAO-A and MAO-B); disrupts the interaction between LSD1 and growth factor-independent 1B (GFI1B) in leukemia cell lines, exhibites significant antitumor efficacy in AEL and AMKL xenograft models. |
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| References | References 1. Takagi S, et al. Cancer Res. 2017 Jun 30. pii: canres.3502.2016. 2. Ishikawa Y, et al. Mol Cancer Ther. 2017 Feb;16(2):273-284. View Related Products by Target Histone Demethylase |
| Molecular Formula | C18H22N4O |
|---|---|
| Molecular Weight | 310.401 |
| InChIKey | NTRMVYTYDOLCRU-DLBZAZTESA-N |
| SMILES | Cn1cc(C(=O)Nc2ccc(C3CC3NCC3CC3)cc2)cn1 |