Antitumor agent-87
Modify Date: 2024-04-05 22:29:41
Antitumor agent-87 structure
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Common Name | Antitumor agent-87 | ||
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| CAS Number | 1422527-88-5 | Molecular Weight | 448.53 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C22H28N2O6S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Antitumor agent-87Antitumor agent-87 is a potent antitumor agent. Antitumor agent-87 shows a high affinity for CYP1A1 with a Ki value of 0.23 µM. Antitumor agent-87 shows antiproliferative activity. Antitumor agent-87 induces cell cycle arrest at the G2/M phase. Antitumor agent-87 show antitumoral activity[1]. |
| Name | Antitumor agent-87 |
|---|
| Description | Antitumor agent-87 is a potent antitumor agent. Antitumor agent-87 shows a high affinity for CYP1A1 with a Ki value of 0.23 µM. Antitumor agent-87 shows antiproliferative activity. Antitumor agent-87 induces cell cycle arrest at the G2/M phase. Antitumor agent-87 show antitumoral activity[1]. |
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| Related Catalog | |
| Target |
CYP1A1:0.23 μM (Ki) |
| In Vitro | Antitumor agent-87 (compound 10) 在人肝微粒体、小鼠肝微粒体和大鼠肝微粒体中的半衰期 (t1/2) 分别为 70、44、107 分钟[1]。 Antitumor agent-87 (1250 nM) 诱导细胞周期停滞在 G2/M 期[1]。 Antitumor agent-87 (0-12500 nM; 72 h) 具有抗增殖活性，对 HT-1080CYP1A1, HT-1080empty, HT-1080, MDA-MB-231, MDA-MB-468, T47D, SK-BR-3, MCF7细胞的 IC50 值分别为 500, 8800, 6800, >12500, 210, 1100, 79, 43 nM[1]。 Cell Proliferation Assay[1] Cell Line: MCF7, HT-29, M21 cells Concentration: 0-12500 nM Incubation Time: 48 h Result: Showed antiproliferative activity with IC50s of 600, >12500, >12500 nM for MCF7, HT-29, M21 cells, respectively. Cell Cycle Analysis[1] Cell Line: MCF7 cells Concentration: 1250 nM Incubation Time: Result: Induced the accumulation of the cells in the G2/M phase of 57% and induced disruptions of the cytoskeleton of MCF7 cells. |
| In Vivo | Antitumor agent-87 (0.1 µg/egg) 在鸡胚中表现出抗肿瘤活性[1]。 Animal Model: chick embryos (HT-1080CYP1A1, HT-1080empty, HT-1080 cells)[1] Dosage: 0.1 µg/egg Administration: Result: Did not show statistically significant antitumor activity on grafted cell lines devoid of CYP1A1 (HT-1080 and HT-1080empty), showed antitumoral inhibition of 29% on the grafted HT-1080CYP1A1. |
| References |
| Molecular Formula | C22H28N2O6S |
|---|---|
| Molecular Weight | 448.53 |
| InChIKey | XXRAJTONBHBJIY-UHFFFAOYSA-N |
| SMILES | CCCCCN1CCN(c2ccc(S(=O)(=O)Oc3cc(OC)cc(OC)c3)cc2)C1=O |