AC 186

Modify Date: 2025-08-25 20:16:41

AC 186 Structure
AC 186 structure
 Common Name AC 186
CAS Number 1421854-16-1 Molecular Weight 306.322
Density 1.3±0.1 g/cm3 Boiling Point 396.9±42.0 °C at 760 mmHg
Molecular Formula C18H17F3O Melting Point N/A
MSDS N/A Flash Point 172.4±22.4 °C

 Use of AC 186


AC-186 is a selective non-steroidal estrogen receptor β (ERβ) agonist with EC50s of 6 nM and 5000 nM for ERβ and ERα, respectively. AC-186 shows gender specific neuroprotection in a Parkinson’s Disease rat model[1].

 Names

Name AC-186
Synonym More Synonyms

 AC 186 Biological Activity

Description AC-186 is a selective non-steroidal estrogen receptor β (ERβ) agonist with EC50s of 6 nM and 5000 nM for ERβ and ERα, respectively. AC-186 shows gender specific neuroprotection in a Parkinson’s Disease rat model[1].
Related Catalog
Target

ERβ:6 nM (EC50)

ERα:5000 nM (EC50)

References

[1]. McFarland K, et al. AC-186, a selective nonsteroidal estrogen receptor β agonist, shows gender specific neuroprotection in a Parkinson's disease rat model. ACS Chem Neurosci. 2013 Sep 18;4(9):1249-55.

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 396.9±42.0 °C at 760 mmHg
Molecular Formula C18H17F3O
Molecular Weight 306.322
Flash Point 172.4±22.4 °C
Exact Mass 306.123138
LogP 4.24
Vapour Pressure 0.0±1.0 mmHg at 25°C
Index of Refraction 1.566

 Synonyms

4-[4,4-Difluoro-1-(2-fluorophenyl)cyclohexyl]phenol
Phenol, 4-[4,4-difluoro-1-(2-fluorophenyl)cyclohexyl]-
AC-186
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Chemsrc provides AC 186(CAS#:1421854-16-1) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of AC 186 are included as well.>> amp version: AC 186

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