5-Me-3’-dU-2’-phosphoramidite

Modify Date: 2025-08-26 16:34:51

5-Me-3’-dU-2’-phosphoramidite Structure
5-Me-3’-dU-2’-phosphoramidite structure
Common Name 5-Me-3’-dU-2’-phosphoramidite
CAS Number 142103-12-6 Molecular Weight 744.81
Density N/A Boiling Point N/A
Molecular Formula C40H49N4O8P Melting Point N/A
MSDS N/A Flash Point N/A

 Use of 5-Me-3’-dU-2’-phosphoramidite


5-Me-3’-dU-2’-phosphoramidite is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

 Names

Name 3'-dt cep
Synonym More Synonyms

 5-Me-3’-dU-2’-phosphoramidite Biological Activity

Description 5-Me-3’-dU-2’-phosphoramidite is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
Related Catalog
References

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.  

 Chemical & Physical Properties

Molecular Formula C40H49N4O8P
Molecular Weight 744.81
Exact Mass 744.32900
PSA 150.86000
LogP 6.81958
InChIKey GYSQEEMWSGWZLC-SXIXUTRBSA-N
SMILES COc1ccc(C(OCC2CC(OP(OCCC#N)N(C(C)C)C(C)C)C(n3cc(C)c(=O)[nH]c3=O)O2)(c2ccccc2)c2ccc(OC)cc2)cc1

 Synthetic Route

~64%

5-Me-3’-dU-2’-phosphoramidite Structure

5-Me-3’-dU-2’-p...

CAS#:142103-12-6

Literature: Rizzo; Dougherty; Breslow Tetrahedron Letters, 1992 , vol. 33, # 29 p. 4129 - 4132

~80%

5-Me-3’-dU-2’-phosphoramidite Structure

5-Me-3’-dU-2’-p...

CAS#:142103-12-6

Literature: Kumar, Anil; Katti, Seturam B.; Madhusudanan, Kunnath P. Nucleosides and Nucleotides, 1997 , vol. 16, # 1-2 p. 11 - 22

~%

5-Me-3’-dU-2’-phosphoramidite Structure

5-Me-3’-dU-2’-p...

CAS#:142103-12-6

Literature: Rizzo; Dougherty; Breslow Tetrahedron Letters, 1992 , vol. 33, # 29 p. 4129 - 4132

~%

5-Me-3’-dU-2’-phosphoramidite Structure

5-Me-3’-dU-2’-p...

CAS#:142103-12-6

Literature: Rizzo; Dougherty; Breslow Tetrahedron Letters, 1992 , vol. 33, # 29 p. 4129 - 4132

~%

5-Me-3’-dU-2’-phosphoramidite Structure

5-Me-3’-dU-2’-p...

CAS#:142103-12-6

Literature: Rizzo; Dougherty; Breslow Tetrahedron Letters, 1992 , vol. 33, # 29 p. 4129 - 4132

 Synonyms

5-METHYL-3'-DU CEP
3'-Deoxy-5'-O-DMT-5-methyluridine 2'-CE phosphoramidite
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