AZD4721
Modify Date: 2025-09-27 07:40:05
AZD4721 structure
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Common Name | AZD4721 | ||
|---|---|---|---|---|
| CAS Number | 1418112-77-2 | Molecular Weight | 472.55 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C19H25FN4O5S2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of AZD4721AZD4721 (RIST4721) is the potent and orally active antagonist of acidic CXC chemokine receptor 2 (CXCR2). AZD4721 has the potential for the research of inflammatory disease[1]. |
| Name | AZD4721 |
|---|
| Description | AZD4721 (RIST4721) is the potent and orally active antagonist of acidic CXC chemokine receptor 2 (CXCR2). AZD4721 has the potential for the research of inflammatory disease[1]. |
|---|---|
| Related Catalog | |
| Target |
CXCR2[1] |
| In Vivo | Assessment of Pharmacokinetics (PK) profile of AZD4721 (RIST4721) in rat and dog[1] . In Vivo PK Rat Dog Predicted hepatic metabolic CL (ml/min per kilogram) 1.7 0.80 Observed CL (ml/min per kilogram) 2.4 0.50 CLrenal (mL/min per kilogram) <0.01 <0.01 CLbiliary (mL/min per kilogram) <0.01 0.04 In vivo/in vitro unbound CLintc 1.4 0.6 VSS (l/kg) 0.19 0.15 T1/2 (h) (PO) 1.3 3.7 (2.7) (8.4) F (%) 45 82 |
| References |
| Molecular Formula | C19H25FN4O5S2 |
|---|---|
| Molecular Weight | 472.55 |
| InChIKey | UCCNQCNIPRKLRP-CJNGLKHVSA-N |
| SMILES | CC1CN(S(=O)(=O)Nc2cc(OC(C)C(O)CO)nc(SCc3ccc(F)cc3)n2)C1 |