AZD4721

Names

[ Name ]:
AZD4721

Biological Activity

[Description]:

AZD4721 (RIST4721) is the potent and orally active antagonist of acidic CXC chemokine receptor 2 (CXCR2). AZD4721 has the potential for the research of inflammatory disease[1].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> CXCR

Research Areas >> Inflammation/Immunology

Signaling Pathways >> Immunology/Inflammation >> CXCR

[Target]

CXCR2[1]

[In Vivo]

Assessment of Pharmacokinetics (PK) profile of AZD4721 (RIST4721) in rat and dog[1] . In Vivo PK Rat Dog Predicted hepatic metabolic CL (ml/min per kilogram) 1.7 0.80 Observed CL (ml/min per kilogram) 2.4 0.50 CLrenal (mL/min per kilogram) <0.01 <0.01 CLbiliary (mL/min per kilogram) <0.01 0.04 In vivo/in vitro unbound CLintc 1.4 0.6 VSS (l/kg) 0.19 0.15 T1/2 (h) (PO) 1.3 3.7 (2.7) (8.4) F (%) 45 82

[References]

[1]. Gardiner P, et al. Plasma Protein Binding as an Optimizable Parameter for Acidic Drugs. Drug Metab Dispos. 2019;47(8):865-873.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₉H₂₅FN₄O₅S₂

[ Molecular Weight ]:
472.55

Related Compounds

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