Cholesteryl oleate-d7

Modify Date: 2024-01-29 18:35:24

Cholesteryl oleate-d7 Structure
Cholesteryl oleate-d7 structure
Common Name Cholesteryl oleate-d7
CAS Number 1416275-35-8 Molecular Weight 658.14
Density N/A Boiling Point N/A
Molecular Formula C45H71D7O2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Cholesteryl oleate-d7


Cholesteryl oleate-d7 is deuterium labeled Cholesteryl oleate. Cholesteryl oleate is an esterified form of Cholesterol. Cholesteryl oleate can be used in the generation of solid lipid nanoparticle (SLN, a nanoparticle-based method for gene therapy)[1

 Names

Name Cholesteryl oleate-d7

 Cholesteryl oleate-d7 Biological Activity

Description Cholesteryl oleate-d7 is deuterium labeled Cholesteryl oleate. Cholesteryl oleate is an esterified form of Cholesterol. Cholesteryl oleate can be used in the generation of solid lipid nanoparticle (SLN, a nanoparticle-based method for gene therapy)[1
Related Catalog
In Vitro Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[3].
References

[1]. Souza SL, et al. Study of the miscibility of cholesteryl oleate in a matrix of ceramide, cholesterol and fatty acid. Chem Phys Lipids. 2011 Oct;164(7):664-71.

[2]. Suñé-Pou M, et, al. Cholesteryl oleate-loaded cationic solid lipid nanoparticles as carriers for efficient gene-silencing therapy. Int J Nanomedicine. 2018 May 30;13:3223-3233.

[3]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-223.

 Chemical & Physical Properties

Molecular Formula C45H71D7O2
Molecular Weight 658.14